Microvascular Response in Diabetes Mellitus
Information source: University Hospital, Angers
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Diabetes Mellitus
Intervention: local heating (Device); iontophoresis (Device); actylcholine (Drug); sodium nitroprusside (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: University Hospital, Angers Official(s) and/or principal investigator(s): Jean Louis Saumet, MD PhD, Principal Investigator, Affiliation: Centre Hospitalier Universitaire Angers
Overall contact: Jean Louis Saumet, MD PhD, Phone: +33 (0) 241.35.36.89
Summary
Vascular and neurological mechanisms are both likely to be involved in foot ulcer. We
recently reported on the hand an original transient pressure-induced vasodilation (PIV)
during a 5 mmHg/min increase of pressure strain using laser Doppler flowmetry. This
physiological response to non noxious external local pressure strain is a widely protective
cutaneous mechanism. The impairment of PIV in diabetic subjects may be relevant to the high
prevalence of foot ulcer that occurs in these individuals. The aim of the project is to
analyse the different physiopathological processes involved in PIV impairment in diabetic
subjects as compared to matched controls.
Clinical Details
Official title: Microcirculation cutanée et Vasodilatation Induite Par la Pression Non-Nociceptive Chez Les diabètiques
Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional
Detailed description:
The whole study is a prospective observational study of diabetic type 1 and type 2 subjects
focusing on the various physical, physiopathological or pharmacological mechanisms that may
interfere with the normal response of the cutaneous microcirculation. The study is currently
conducted under various parallel groups of patients and control subjects matched on age and
sexe. Techniques used for the study are only non-invasive investigations such as
iontophoresis with laser doppler flowmetry, clinical and paraclinical non-invasive
investigation of peripheral neuropathy, ultrasound imaging of peripheral arteries.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Diabetes
Exclusion Criteria:
- Non diabetic neuropathy
- Peripheral arterial disease
- pregnancy
Locations and Contacts
Jean Louis Saumet, MD PhD, Phone: +33 (0) 241.35.36.89
Centre hospitalier universitaire, Angers 49933, France; Recruiting Pierre Abraham, MD, PhD Pierre Abraham, MD PhD, Sub-Investigator
Additional Information
Related publications: Koïtka A, Legrand-Fernandez MS, Abraham P, Fizanne L, Fromy B, Sigaudo-Roussel D, Saumet JL. Low skin temperature impairs the cutaneous vasodilator response to local progressive pressure strain. Microvasc Res. 2004 Mar;67(2):203-6. Koïtka A, Abraham P, Bouhanick B, Sigaudo-Roussel D, Demiot C, Saumet JL. Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes. Diabetes. 2004 Mar;53(3):721-5.
Starting date: January 2003
Last updated: March 16, 2007
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