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Microvascular Response in Diabetes Mellitus

Information source: University Hospital, Angers
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Diabetes Mellitus

Intervention: local heating (Device); iontophoresis (Device); actylcholine (Drug); sodium nitroprusside (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: University Hospital, Angers

Official(s) and/or principal investigator(s):
Jean Louis Saumet, MD PhD, Principal Investigator, Affiliation: Centre Hospitalier Universitaire Angers

Overall contact:
Jean Louis Saumet, MD PhD, Phone: +33 (0) 241.35.36.89

Summary

Vascular and neurological mechanisms are both likely to be involved in foot ulcer. We recently reported on the hand an original transient pressure-induced vasodilation (PIV) during a 5 mmHg/min increase of pressure strain using laser Doppler flowmetry. This physiological response to non noxious external local pressure strain is a widely protective cutaneous mechanism. The impairment of PIV in diabetic subjects may be relevant to the high prevalence of foot ulcer that occurs in these individuals. The aim of the project is to analyse the different physiopathological processes involved in PIV impairment in diabetic subjects as compared to matched controls.

Clinical Details

Official title: Microcirculation cutanée et Vasodilatation Induite Par la Pression Non-Nociceptive Chez Les diabètiques

Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional

Detailed description: The whole study is a prospective observational study of diabetic type 1 and type 2 subjects focusing on the various physical, physiopathological or pharmacological mechanisms that may interfere with the normal response of the cutaneous microcirculation. The study is currently conducted under various parallel groups of patients and control subjects matched on age and sexe. Techniques used for the study are only non-invasive investigations such as iontophoresis with laser doppler flowmetry, clinical and paraclinical non-invasive investigation of peripheral neuropathy, ultrasound imaging of peripheral arteries.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Diabetes

Exclusion Criteria:

- Non diabetic neuropathy

- Peripheral arterial disease

- pregnancy

Locations and Contacts

Jean Louis Saumet, MD PhD, Phone: +33 (0) 241.35.36.89

Centre hospitalier universitaire, Angers 49933, France; Recruiting
Pierre Abraham, MD, PhD
Pierre Abraham, MD PhD, Sub-Investigator
Additional Information

Related publications:

Koïtka A, Legrand-Fernandez MS, Abraham P, Fizanne L, Fromy B, Sigaudo-Roussel D, Saumet JL. Low skin temperature impairs the cutaneous vasodilator response to local progressive pressure strain. Microvasc Res. 2004 Mar;67(2):203-6.

Koïtka A, Abraham P, Bouhanick B, Sigaudo-Roussel D, Demiot C, Saumet JL. Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes. Diabetes. 2004 Mar;53(3):721-5.

Starting date: January 2003
Last updated: March 16, 2007

Page last updated: August 23, 2015

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