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Ketamine Versus Etomidate for Rapid Sequence Intubation

Information source: Minneapolis Medical Research Foundation
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Airway Control; Anesthesia; Intubation; Complication

Intervention: Ketamine (Drug); Etomidate (Drug)

Phase: Phase 4

Status: Suspended

Sponsored by: Minneapolis Medical Research Foundation

Official(s) and/or principal investigator(s):
Brian E Driver, MD, Principal Investigator, Affiliation: Hennepin County Medical Canter


The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).

Clinical Details

Official title: Ketamine Versus Etomidate for Sedation of Emergency Department Patients During Rapid Sequence Intubation

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Mortality

Secondary outcome:

Mortality in Sepsis and Septic Shock

First-pass success

Number of intubation attempts

Post-intubation sedation

Post-intubation hypoxemia


SOFA score

Peak and Plateau pressure

Detailed description: This study is a randomized controlled trial of etomidate versus ketamine during rapid sequence intubation (RSI). RSI refers to the process by which patients who require emergency airway management undergo sedation and paralysis prior to insertion of an endotracheal tube(airway tube). Patients who require intubation will be randomized to have intubation performed with either ketamine or etomidate. All other care will be at the discretion of the treating physicians. The purpose of this study is to compare the efficacy and safety of ketamine and etomidate during rapid sequence intubation.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- 18 years of age

- Undergoing rapid sequence intubation (RSI) in the Emergency Department

Exclusion Criteria:

- Known contraindication to ketamine or etomidate

- Patient declines participation in the trial by wearing a bracelet marked "KvE


- Prisoner

Locations and Contacts

Hennepin County Medical Center, Minneapolis, Minnesota 55415, United States
Additional Information

Public description of study protocol.

Starting date: September 2013
Last updated: October 23, 2014

Page last updated: August 23, 2015

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