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hCG Supplementation in Frozen-Thawed Embryo Transfer Cycle

Information source: Hadassah Medical Organization
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Fertility Agents, Female

Intervention: s.c. human chorionic gonadotropin (Ovitrelle) (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Hadassah Medical Organization

Official(s) and/or principal investigator(s):
Assaf Ben-Meir, MD, Principal Investigator, Affiliation: Hadassah Medical Organization

Summary

The implantation rate after frozen-thawed embryo transfer cycles depends mostly on the receptivity of the endometrium and the embryo quality. The effects of human chorionic gonadotropins (hCG) on the endometrium have been investigated for several years. hCG was shown to up-regulate gene expression during the differentiation of human endometrial stromal cells into decidua. The aim of our study was to assess the benefit of hCG supplementation throughout the secretory phase of artificial frozen-thawed embryo transfer cycles.

Clinical Details

Official title: The Benefit of Human Chorionic Gonadotropin (hCG) Supplementation Throughout the Secretory Phase of Frozen-Thawed Embryo Transfer Cycles

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

implantation rate

pregnancy rate

Eligibility

Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- all women on frozen-thawed embryo-transfer cycle

Exclusion Criteria:

- any allergy to injection of human chorionic gonadotropin before

Locations and Contacts

Hadassah Medical center, Jerusalem, Israel
Additional Information

Starting date: November 2006
Last updated: December 31, 2008

Page last updated: August 23, 2015

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