The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism
Information source: Gulhane School of Medicine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypogonadotrophic Hypogonadism
Intervention: Testogel 50 mg transdermal gel (Drug); Testosterone 250mg injection (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Gulhane School of Medicine
Summary
The study searched for answers to two questions
1. What is the effect of testosterone replacement therapy on endothelial dysfunction,
inflammation and insulin resistance?
2. Regarding the above parameters, is there any difference between daily transdermal
testosterone implementation and intramuscular injection performed in three weeks.
Clinical Details
Official title: Phase 4 Study That Evaluates the Effects of Two Different Testosterone Replacement Regiments on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Subjects With Hypogonadotrophic Hypogonadism.
Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: The alterations in the measures for endothelial functionsThe alterations in the measures of insulin resistance The alterations in the measures of inflammation
Eligibility
Minimum age: 18 Years.
Maximum age: 26 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Men
- Treatment naive
- Hypogonadotrophic hypogonadism
Exclusion Criteria:
- Previous history of androgen replacement
- Chronic metabolic disorders
Locations and Contacts
Gulhane School of Medicine Department of Endocrinology and Metabolism, Ankara, Non US 06018, Turkey
Additional Information
Starting date: August 2008
Last updated: February 14, 2012
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