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Branched Chain Aminoacid Supplementation in Patients With Liver Cirrhosis

Information source: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Liver Cirrhosis

Intervention: Branched-chain aminoacids (Dietary Supplement); High-fiber high protein diet (Other)

Phase: Phase 4

Status: Completed

Sponsored by: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran


Malnutrition is a frequent complication in patients with liver cirrhosis. Most patients have decreased dietary intake due to ascites, hepatic encephalopathy and pro-inflammatory cytokines. We hypothesized that branched chain aminoacids can improve nutritional status and delay episodes of hepatic encephalopathy

Clinical Details

Official title: High-fiber High-fiber Diet and Branched Chain Aminoacids. Impact on Nutritional Status and Complications in Patients With Liver Cirrhosis

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Nutritional status

Secondary outcome: Hepatic Encephalopathy


Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.


Inclusion Criteria: Ambulatory patients Patients with confirmed diagnose of liver cirrhosis Patients classified as Child-Pugh A or Child Pugh B Exclusion Criteria: Acute or chronic renal failure Pregnancy Overt hepatic encephalopathy

Locations and Contacts

Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico city 14000, Mexico
Additional Information

Starting date: January 2011
Last updated: December 23, 2013

Page last updated: August 23, 2015

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