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Micro Ribonucleic Acid (RNA) as Cholinergic Tone and Inflammatory Regulator in Inflammatory Bowel Disease

Information source: Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Inflammatory Bowel Disease

Phase: N/A

Status: Not yet recruiting

Sponsored by: Tel-Aviv Sourasky Medical Center

Overall contact:
Nitsan Maharshak, MD, Phone: +972-3-6974282, Email: nitzanm@tasmc.health.gov.il


There is a reciprocal relationship between the central nervous system and the immune system. Stimulation of the vagus nerve results in secretion of acetylcholine (Ach) which decreases secretion of pro-inflammatory cytokines. Acetylcholine esterase is an enzyme that neutralizes Ach and thus, involves in regulation of Ach levels, and in the cholinergic tone and inflammatory state. MicroRNAs (miRs) are evolutionarily conserved, RNAs that regulate gene expression. The investigators hypothesized that miRs controlling systemic communication processes function in one tissue in response to signals (i. e. neuronal, hormonal or others) from another. Specifically, the investigators hypothesized that miRs control the inflammatory response in inflammatory bowel diseases through regulation of expression of messenger RNA of AchE.

Clinical Details

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: Elevated expression of specific micro RNAs that regulate the expression of the enzyme Acetylcholine esterase in inflammatory bowel disease patients compared to healthy controls.

Secondary outcome: A statistically significant relation between micro RNA expression and disease activity and inflammatory indices


Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.


Inclusion Criteria:

- Inflammatory bowel disease patients under going colonoscopy

Exclusion Criteria:

- Debilitated patients who need an apotropsy

- Age < 18 or age > 75

- Pregnant women

- Evidence of previous or current cancer

- Inflammatory disease other than IBD

Locations and Contacts

Nitsan Maharshak, MD, Phone: +972-3-6974282, Email: nitzanm@tasmc.health.gov.il

Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Not yet recruiting
Nitsan Maharshak, MD, Principal Investigator
Additional Information

Starting date: September 2008
Last updated: August 13, 2008

Page last updated: August 23, 2015

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