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Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients

Information source: Shanghai Jinshan Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Primary Open-angle Glaucoma

Intervention: Vitamin A (Drug); carbomer eye gel (Drug)

Phase: N/A

Status: Completed

Sponsored by: Xiaodong Zhou

Summary

Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: change of the density of conjunctival goblet cells

Secondary outcome:

tear film parameters changes in patients

changes of ocular irritation in patients

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- diagnosed primary open-angle glaucoma or normal tension glaucoma patients with

prostaglandin analogs treatment for more than one year. Exclusion Criteria: 1. any systemic diseases which may cause ocular damage; 2. previous ocular trauma or surgery; 3. contact lens wear history in previous 6 months; 4. application of any artificial tears 3 months ago; 5. allergic to any of the drugs we used during examination.

Locations and Contacts

Additional Information

Starting date: September 2011
Last updated: March 3, 2014

Page last updated: August 20, 2015

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