Study of Vitamin A and Carbomer in Comforting the Ocular Surface Irritations of Glaucoma Patients
Information source: Shanghai Jinshan Hospital
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Primary Open-angle Glaucoma
Intervention: Vitamin A (Drug); carbomer eye gel (Drug)
Phase: N/A
Status: Completed
Sponsored by: Xiaodong Zhou
Summary
Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular
surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to
search for new drugs for therapy. The investigators hypothesized that the artificial tears
containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in
common use and had already been tested in animals.
Clinical Details
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: change of the density of conjunctival goblet cells
Secondary outcome: tear film parameters changes in patientschanges of ocular irritation in patients
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- diagnosed primary open-angle glaucoma or normal tension glaucoma patients with
prostaglandin analogs treatment for more than one year.
Exclusion Criteria:
1. any systemic diseases which may cause ocular damage;
2. previous ocular trauma or surgery;
3. contact lens wear history in previous 6 months;
4. application of any artificial tears 3 months ago;
5. allergic to any of the drugs we used during examination.
Locations and Contacts
Additional Information
Starting date: September 2011
Last updated: March 3, 2014
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