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Bortezomib in Combination With CC-5013 in Patients With Relapsed/Refractory Multiple Myeloma

Information source: Dana-Farber Cancer Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Multiple Myeloma

Intervention: Bortezomib (Drug); CC-5013 (Drug)

Phase: Phase 1

Status: Active, not recruiting

Sponsored by: Dana-Farber Cancer Institute

Official(s) and/or principal investigator(s):
Paul Richardson, MD, Principal Investigator, Affiliation: Dana-Farber Cancer Institute

Summary

The purpose if this study is to evaluate the side effects of the combination of bortezomib and Revlimid (CC-5013) in patients with relapsed and relapsed/refractory multiple myeloma.

Clinical Details

Official title: An Open-Label Phase I Study of the Safety and Efficacy of Bortezomib in Combination With CC-5013 in the Treatment of Subjects With Relapsed and Relapsed/Refractory Multiple Myeloma

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: To evaluate the safety of bortezomib when given in combination with CC-5013 in subjects with relapsed and relapsed/refractory multiple myeloma, to identify the MTD as well as a RP2D.

Secondary outcome:

To evaluate the response of the combination of bortezomib and CC-5013

To determine the pharmacokinetics of bortezomib and CC5013 in patients with multiple myeloma.

Detailed description:

- Within 21 days of starting treatment the following tests will be performed: physical

exam (including vital signs), ECG, neurological examination, blood tests, urine tests, bone marrow aspiration, x-rays and MRI or CT scan.

- Patients will receive bortezomib intravenously on day 1,4,8 and 11 followed by 10 days

of rest. CC-5013 will be given orally on days 1-14 followed by 7-dyas of rest. One cycle lasts 21 days. This study will evaluate different dose levels of bortezomib and CC-5013 to see which dose level seems to be the best for most people. There will be 8 dose levels.

- Patients will be assigned to a dose level depending upon when they begin the study and

how other dose levels have been tolerated by patients that are already on the study. Three to six patients will be treated at each dose level and will be observed for one full cycle. Depending upon the side effects, the dose level will increase, stay the same or be decreased by one level for the next group. 10 additional patients will be treated at the dose that is thought the best.

- On day four of the treatment cycle blood tests, vital signs and a review of side

effects will be performed.

- On day eight of the the treatment cycle blood tests, vital signs, review of side

effects and an ECG will be performed prior to medication administration. A bortezomib level will be taken before bortezomib infusion, 15 minutes, 1/2 hour, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 8 hours and 12 hours after the dose. Additional blood levels will be collected 24, 48, and 72 hours after the dose. (These blood levels will done during the first cycle only).

- On day 11 and day 14 of the treatment cycle blood tests, vital signs and review of side

effects will be performed.

- After 2 cycles of treatment, the doctor will assess how the patient's disease is

responding to the treatment. Additional tests such as bone marrow biopsy, x-rays or scans may be performed. If the disease is stable or getting better, patients will continue to receive repeated cycles of treatment. If the disease is getting worse, dexamethasone may be added to the treatment cycle.

- If dexamethasone is added, the dosing will start on days 1,2,4,5,8,9 and 11 of the

21-day cycle. The disease will then be reassessed after 2 additional cycles. If the disease is getting worse, the patient will be removed from the study.

- Once 8 cycles of treatment have been performed, the disease will be fully assessed

again by blood tests, bone marrow biopsy, x-rays or scans. Again, if it is determined that the disease is stable of getting better, additional treatment cycles can be performed. If the disease is getting worse, treatment will be stopped..

- A follow-up visit will be scheduled one month after the last dose of the study drug and

will include: physical exam, vital signs, neurological examination, and review of symptoms.

- Patients will remain on this study as long as the side effects are not too severe and

the disease has not progressed.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Diagnosis of multiple myeloma based on standard diagnosis criteria: plasmacytomas on

tissue biopsy; bone marrow plasmacytosis; monoclonal immunoglobulin spike on serum electrophoresis; lytic bone lesions.

- Must have relapsed or relapsed/refractory disease

- 18 years of age or older

- All baseline studies must be performed within 21 days of enrollment.

- ECOG performance status of 0 to 2

Exclusion Criteria:

- Renal insufficiency (serum creatinine levels > 2mg/dL)

- Concomitant therapy medications that include corticosteroids

- Peripheral neuropathy of Grade 3 or greater or painful Grade 2

- Evidence of mucosal or internal bleeding and/or platelet refractory

- ANC < 1000 cells/mm3

- Hemoglobin < 8. 0 g/dL

- AST (SGOT and ALT) > 2 x ULN

- Intolerance to bortezomib or CC-5013 in the past or significant allergy to either

compound, boron or mannitol

- Known hypersensitivity to thalidomide or the development of erythema nodosum

- Active infection or serious co-morbid medical condition

- Pregnant or breast-feeding women

- Prior malignancy with the last three years except adequately treated basal cell or

squamous cell skin cancer, in situ cervical cancer, in situ breast cancer, on in-situ prostate cancer

Locations and Contacts

H. Lee Moffitt Cancer Center, Tampa, Florida 33612, United States

Winship Cancer Center, Atlanta, Georgia 30322, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, United States

Dana-Farber Cancer Center, Boston, Massachusetts 02115, United States

University of Michigan, Ann Arbor, Michigan 48109, United States

St. Vincent's Comprehensive Cancer Center, New York City, New York 10011, United States

Additional Information

Starting date: August 2004
Last updated: October 15, 2013

Page last updated: August 23, 2015

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