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A Comparative Study of ID Fellow-based VS. Pharmacist-based Antibiotic Pre-authorization

Information source: Siriraj Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: All Hospitalzied Patients; No Specific Conditions Requires

Intervention: ID fellow-based antibiotic pre-authorization (Procedure); Pharmacist-based antibiotic pre-authorization (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: Siriraj Hospital

Official(s) and/or principal investigator(s):
Pinyo Rattanaumpawan, MD, MSCE, Principal Investigator, Affiliation: Mahidol University


We will conduct a cluster randomized controlled trial to compare two antibiotic pre-authorization strategies (Fellow-based vs. Pharmacist-based). We believe that amount and duration of antibiotic consumption would be lower in the pharmacist group while the clinical outcome would be equivalent between two groups.

Clinical Details

Official title: A Comparative Study of ID Fellow-based Pre-authorization VS. Pharmacist-based Pre-authorization in Reducing Antibiotic Consumptions and Hospital Expenditures

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Defined Daily Dose (DDD) of antibiotics

Secondary outcome: Total duration of antibiotic use

Detailed description: Study design: A cluster randomized controlled trial Settings: 6 general medical wards at Siriraj Hospital, Bangkok, Thailand


Minimum age: 15 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Hospitalized patients

- Received at least one dose of controlled antibiotics (Piperacillin/Tazobactam,

Imipenem/Cilastatin, Meropenem or Doripenem)

- Each patient may be enrolled more than once, if he/she receives the controlled

antibiotic for a new episode of infection (at least 48 hour apart) Exclusion Criteria:

- Died prior to receive the controlled antibiotic

Locations and Contacts

Siriraj Hospital, Bangkok 10700, Thailand; Recruiting
Pinyo Rattanaumpawan, MD, MSCE, Phone: 6624197783, Email: pinyo.rat@mahidol.ac.th
Pinyo Rattanaumpawan, MD, MSCE, Principal Investigator
Additional Information

Starting date: February 2013
Last updated: February 20, 2013

Page last updated: August 23, 2015

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