Metoclopramide for Migraine: A Dose Finding Study
Information source: Montefiore Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Migraine
Intervention: metoclopramide (Drug); metoclopramide (Drug); metoclopramide (Drug); Diphenhydramine 25mg (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: Montefiore Medical Center Official(s) and/or principal investigator(s):
Benjamin W. Friedman, MD, MS, Principal Investigator, Affiliation: Montefiore Medical Center
Summary
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do
not know the best dose to administer. This study compares three different doses of
metoclorpamide.
Clinical Details
Official title: Metoclopramide for Acute Migraine: A Dose Finding Study
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Pain Intensity Score
Detailed description:
Patients with acute migraine attacks are eligible for enrollment if they present to the
emergency department of Montefiore Medical Center. Pain scores are assessed at baseline and
every 30 minutes for two hours, and then again by telephone 48 hours after discharge
Eligibility
Minimum age: 18 Years.
Maximum age: 69 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- acute migraine
Exclusion Criteria:
- secondary cause of headache
- lumbar puncture
- allergy or intolerance to study medication
Locations and Contacts
Montefiore Medical Center, Bronx, New York 10467, United States
Additional Information
Starting date: April 2008
Last updated: November 28, 2012
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