Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation
Information source: Valduce Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Atrial Fibrillation
Intervention: electrical cardioversion (Procedure); propafenone (Drug)
Phase: N/A
Status: Completed
Sponsored by: Valduce Hospital
Summary
The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of
less than 48 hours' duration is still controversial. The investigators performed a
controlled single-center trial to compare electrical and pharmacological (propafenone)
cardioversion to restore the sinus rhythm in selected patients with acute atrial
fibrillation.
Clinical Details
Official title: Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Primary outcome: Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm
Secondary outcome: Number of adverse events related to electrical and pharmacological cardioversionrecurrence of atrial fibrillation
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- atrial fibrillation of less than 48 hours' duration.
Exclusion Criteria:
- AF of more than 48 hours'
- hemodynamic instability
- acute onset atrial fibrillation due to acute coronary syndrome
- electrolyte disturbances
- sepsis
- fever
- hypothermia
- untreated hyperthyroidism
- use of antiarrhythmic drugs
- high embolic risk
- unclear duration of symptoms
Locations and Contacts
Emergency Unit - Valduce Hospital, Como 22100, Italy
Additional Information
Starting date: January 2006
Last updated: July 2, 2009
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