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Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline

Information source: Zhujiang Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Chronic Obstructive Pulmonary Disease

Intervention: theophylline (Drug)

Phase: N/A

Status: Completed

Sponsored by: Zhujiang Hospital

Official(s) and/or principal investigator(s):
Wang Liqing, Doctor, Principal Investigator, Affiliation: Zhujiang Hospital,Southern Medical Unversity

Summary

The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.

Clinical Details

Official title: Association Between CytochromeP4501A2(CYP1A2) and CytochromeP4502E1(CYP2E1) Gene Polymorphisms and Metabolism of Theophylline in a Chinese Population

Study design: Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome: Theophylline clearance

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Aged 18-75 years,COPD patients, male or female;

- regularly visiting our hospital;

- taking a sustained-release preparation of theophylline continuously for at least 2

weeks Exclusion Criteria:

- patients with renal or hepatic dysfunction;

- patients with congestive heart failure;

- patients with hypothyroidism or hyperthyroidism;

- patients currently taking drugs likely to affect theophylline metabolism or who had

taken such drugs in the preceding week;

- patients with extreme obesity

- patients with very severe Chronic Obstructive Pulmonary Disease(COPD)

Locations and Contacts

Zhujiang Hospital,Southern Medical Universtiy, Guangzhou, Guangdong 510282, China
Additional Information

Starting date: September 2013
Last updated: August 19, 2014

Page last updated: August 23, 2015

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