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The Role of Serum Anticholinergic Activity in ACVB Patients

Information source: Heidelberg University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acetylcholine; Cognition; BIS-EEG

Phase: N/A

Status: Completed

Sponsored by: Heidelberg University

Official(s) and/or principal investigator(s):
Eike Martin, Prof., Study Chair, Affiliation: Department of Anesthesiology, University of Heidelberg


Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients. The investigators main goal is to identify preoperative risk factors and to monitor postoperative patients' state in relation to SAA activity and bilateral BIS-EEG changes.

Clinical Details

Official title: Serum Anticholinergic Activity (SAA) and BIS-EEG as Potential Markers for Cognitive Ability and/or the Anticholinergic Medication in ACVB Patients

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: Cognitive dysfunction measured by neurocognitive test battery

Secondary outcome: SAA, BIS-EEG, descriptive patients' characteristics


Minimum age: 55 Years. Maximum age: 90 Years. Gender(s): Both.


Inclusion Criteria:

- written compliance to the study participation

- a good knowledge in German speech

- no red/ green blindness

- no previous neurological and/or psychiatric illness

- good ability to see and to hear

- Mini-Mental-State-Examination (MMSE) better than 25 points

Exclusion Criteria:

- no written compliance to the study participation

- bad knowledge in German speech

- red/ green blindness

- previous neurological and/or psychiatric illness

- no ability to see and to hear

- Mini-Mental-State-Examination (MMSE) lower than 25 points

Locations and Contacts

University of Heidelberg, Department of Anesthesiology, Heidelberg Medical School, Heidelberg, BW 69120, Germany
Additional Information

ISPOCD1 study

Starting date: May 2008
Last updated: January 13, 2010

Page last updated: August 23, 2015

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