The Role of Serum Anticholinergic Activity in ACVB Patients
Information source: Heidelberg University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Acetylcholine; Cognition; BIS-EEG
Phase: N/A
Status: Completed
Sponsored by: Heidelberg University Official(s) and/or principal investigator(s): Eike Martin, Prof., Study Chair, Affiliation: Department of Anesthesiology, University of Heidelberg
Summary
Drugs with anticholinergic potential increase the risk of postoperative transient and
persistent cognitive dysfunction especially in cardiac patients. The investigators main goal
is to identify preoperative risk factors and to monitor postoperative patients' state in
relation to SAA activity and bilateral BIS-EEG changes.
Clinical Details
Official title: Serum Anticholinergic Activity (SAA) and BIS-EEG as Potential Markers for Cognitive Ability and/or the Anticholinergic Medication in ACVB Patients
Study design: Observational Model: Case Control, Time Perspective: Prospective
Primary outcome: Cognitive dysfunction measured by neurocognitive test battery
Secondary outcome: SAA, BIS-EEG, descriptive patients' characteristics
Eligibility
Minimum age: 55 Years.
Maximum age: 90 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- written compliance to the study participation
- a good knowledge in German speech
- no red/ green blindness
- no previous neurological and/or psychiatric illness
- good ability to see and to hear
- Mini-Mental-State-Examination (MMSE) better than 25 points
Exclusion Criteria:
- no written compliance to the study participation
- bad knowledge in German speech
- red/ green blindness
- previous neurological and/or psychiatric illness
- no ability to see and to hear
- Mini-Mental-State-Examination (MMSE) lower than 25 points
Locations and Contacts
University of Heidelberg, Department of Anesthesiology, Heidelberg Medical School, Heidelberg, BW 69120, Germany
Additional Information
ISPOCD1 study
Starting date: May 2008
Last updated: January 13, 2010
|