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Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery

Information source: Mahidol University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Morphine

Intervention: 1 mg morphine soak in epidural oxidized cellulose (Drug); normal saline (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Mahidol University


The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study

Clinical Details

Official title: The Effect of Epidural Low-dose Morphine-soaked Microfibrillar Collagen Sponge in Postoperative Pain Control After Posterior Lumbar Spinal Surgery: a Randomized, Double-blind, Placebo-controlled

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Primary outcome: VAS measurement was recorded at twenty-four hour after posterior lumbar spinal surgery then compare VAS between low-dose 1 mg morphine-soaked microfibrillar collagen sponge method with normal saline soked


Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria:

- Age > 18 Yrs

- Good orientation and communication

Exclusion Criteria:

- opioids or sulfonamides allergy

- Contraindication for use

- Epidural morphine

- Selective COX 2 inhibitor

- Patient-controlled analgesia (PCA)

- ASA class > 3

- BMI ≥ 35 kg/sq. m.

- Preoperative use of opioids within 6 Wks

- Intraoperative bleeding > 1000ml

Locations and Contacts

Siriraj hospital, Bangkoknoi, Bangkok 10700, Thailand
Additional Information

Starting date: August 2012
Last updated: February 18, 2014

Page last updated: August 23, 2015

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