Reducing Nephrotoxicity of Vancomycin: A Prospective Study of Continuous Versus Intermittent Infusion of Vancomycin
Information source: National University Hospital, Singapore
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Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Infections Requiring Prolonged Duration (>10 Days) of Vancomycin
Intervention: continuous vancomycin infusion (Drug); intermittent vancomycin infusion (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: National University Hospital, Singapore Overall contact:
Shire Yang Tan, Phone: 97989001, Email: shire_yang_tan@nuhs.edu.sg
Summary
This study is being carried out to find out whether there is reduction in vancomycin-induced
kidney injury (nephrotoxicity) when vancomycin is given as intermittent versus continuous
infusion.
This study will recruit 220 subjects from 2 hospitals over a period of 3 years.
Participants are invited if they have an infection that requires prolonged vancomycin
therapy (> more than 10 days).
Clinical Details
Official title: Reducing Nephrotoxicity of Vancomycin: A Prospective, Randomized Study of Continuous Versus Intermittent Infusion of Vancomycin
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: nephrotoxicity
Secondary outcome: biomarkers for detection of early nephrotoxicity
Eligibility
Minimum age: 21 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Adults aged 21-80 years
- Documented infection requiring prolonged (> 10 days) of vancomycin therapy
- Creatinine clearance > 50 ml/min (using Cockroft-Gault equation)
Exclusion Criteria:
- Patient already received 7 days or more of vancomycin therapy
- Pregnancy
- Severe burns > 40% body surface area
- Spinal cord injuries
- Participation in another interventional trial in previous 30 days
- Inability to obtain informed consent
Locations and Contacts
Shire Yang Tan, Phone: 97989001, Email: shire_yang_tan@nuhs.edu.sg
National University Hospital, Singapore, Singapore; Recruiting
Shire Yang Tan, Phone: 97989001, Email: shire_yang_tan@nuhs.edu.sg
Dale Fisher, Principal Investigator
Additional Information
Starting date: October 2012
Last updated: November 1, 2012
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