Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction
Information source: Rabin Medical Center
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Nocturnal Enuresis
Intervention: Desmopressin (Drug)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: Rabin Medical Center Official(s) and/or principal investigator(s): Ofer Yossepowitch, MD, Principal Investigator, Affiliation: Rabin Medical Center
Summary
The purpose of this study is to prospectively assess whether Desmopressin, given for a
period of month to patients after radical cystectomy with orthotopic bladder reconstruction,
improves and lowers the rate of nocturnal enuresis.
Clinical Details
Official title: Usage of Desmopressin fo Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Orthotopic Bladder Reconstruction
Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Rate of improvement in Nocturnal incontinence
Detailed description:
We will prospectively assess the utilization of Desmopressin in improving nocturnal enuresis
in patients after radical cystectomy with orthotopic bladder reconstruction.
Patients after radical cystectomy with neobladder reconstruction will be given Desmopressin
0. 1 mg once a day for a duration of one month.
Before beginning treatment patients will be given the NNES-Q questionnaire to assess
severity of nocturnal enuresis.
At the end of treatment, the same questionnaire will be given to all patients to assess if
nocturnal enuresis improved.
Sodium levels will be tested before treatment, 2 weeks after beginning treatment and at the
end of treatment.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age above 18
- Able to give informed consent
- Patients afte radical cystectomy with orthotopic bladder reconstruction with night
time incontinence
Exclusion Criteria:
- Patients with after radical cystectomy with orthotopic bladder reconstruction with
daytime urinary incontinence
- Patients already treated with Desmopressin due to other reasons.
- Patients with an allergy or insensitivity to Desmopressin.
- Patients with known hyponatremia
- Patients with severe chronic renal failure and creatinine clearance of below 50
cc/sec.
- Patients with severe congestive heart failure
- Patients with active urinary tract infection
- Patients taking drug therapy which can interact with Desmopressin and affect it's
action. Examples include Diuretics, Tricyclic antidepressants, Carbamezapine and
Chlorpropamide AND Indomethacin.
- Patients with an indwelling urinary catheter.
Locations and Contacts
Institute of Urology, Rabin Medical Cetner, Petah Tiqva, Petach Tiqva 49100, Israel
Additional Information
Starting date: April 2012
Last updated: April 19, 2012
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