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Acetylcholine and Postoperative Cognitive Change in Aged Patients

Information source: RenJi Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Necrosis of Femoral Head; Knee Osteoarthritis; Fracture of Lower Limb

Phase: N/A

Status: Recruiting

Sponsored by: RenJi Hospital

Official(s) and/or principal investigator(s):
Diansan Su, Dr., Study Chair, Affiliation: Renji Hospital, School of Medicine, Shanghai Jiaotong University

Overall contact:
Diansan Su, Doctor, Phone: 0086-21-68383702, Email: diansansu@yahoo.com


Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.

Clinical Details

Official title: Cerebrospinal Fluid Acetylcholine and Postoperative Cognitive Change in Aged Patients

Study design: Observational Model: Case-Only, Time Perspective: Prospective

Primary outcome:

Short-term cognitive changes after surgery

Long-term cognitive changes after surgery

Acetylcholine in CSF


Minimum age: 60 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Elder than 60 years old

- Spoke proficient Chinese

- Agree to undergoing spinal plus general anesthesia

- Selected to lower limb osteopathic surgery

Exclusion Criteria:

- Existing cerebral disease, or have a history of neurological and psychiatric diseases

including AD, stroke, and psychosis

- Have contraindication for spinal anesthesia such as clotting disorder local infection

in the puncture site

- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores

below 24

- Several audition or vision disorder

- Unwillingness to comply with the protocol or procedures.

Locations and Contacts

Diansan Su, Doctor, Phone: 0086-21-68383702, Email: diansansu@yahoo.com

Renji hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai 200127, China; Recruiting
Diansan Su, Dr.
Diansan Su, Dr., Principal Investigator
Lingke Chen, BA, Sub-Investigator
Additional Information

Starting date: April 2014
Last updated: May 27, 2014

Page last updated: August 23, 2015

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