Acetylcholine and Postoperative Cognitive Change in Aged Patients
Information source: RenJi Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Necrosis of Femoral Head; Knee Osteoarthritis; Fracture of Lower Limb
Phase: N/A
Status: Recruiting
Sponsored by: RenJi Hospital Official(s) and/or principal investigator(s): Diansan Su, Dr., Study Chair, Affiliation: Renji Hospital, School of Medicine, Shanghai Jiaotong University
Overall contact: Diansan Su, Doctor, Phone: 0086-21-68383702, Email: diansansu@yahoo.com
Summary
Previous study demonstrated that the condition of central cholinergic nerve is important for
the postoperative cognitive dysfunction. In present study investigators hypothesized that
the acetylcholine concentration in the cerebral spinal fluid is associated to the
postoperative cognitive changes in aged patients undergoing osteopathic surgery.
Clinical Details
Official title: Cerebrospinal Fluid Acetylcholine and Postoperative Cognitive Change in Aged Patients
Study design: Observational Model: Case-Only, Time Perspective: Prospective
Primary outcome: Short-term cognitive changes after surgeryLong-term cognitive changes after surgery Acetylcholine in CSF
Eligibility
Minimum age: 60 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Elder than 60 years old
- Spoke proficient Chinese
- Agree to undergoing spinal plus general anesthesia
- Selected to lower limb osteopathic surgery
Exclusion Criteria:
- Existing cerebral disease, or have a history of neurological and psychiatric diseases
including AD, stroke, and psychosis
- Have contraindication for spinal anesthesia such as clotting disorder local infection
in the puncture site
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores
below 24
- Several audition or vision disorder
- Unwillingness to comply with the protocol or procedures.
Locations and Contacts
Diansan Su, Doctor, Phone: 0086-21-68383702, Email: diansansu@yahoo.com
Renji hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai 200127, China; Recruiting Diansan Su, Dr. Diansan Su, Dr., Principal Investigator Lingke Chen, BA, Sub-Investigator
Additional Information
Starting date: April 2014
Last updated: May 27, 2014
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