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Evaluating the Effect of CHanging EnfuvirtidE to Raltegravir in HIV Infected Subjects

Information source: Kaiser Permanente
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: HIV Infections

Intervention: raltegravir (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Kaiser Permanente

Official(s) and/or principal investigator(s):
William J Towner, MD, Principal Investigator, Affiliation: Kaiser Permanente

Summary

The primary objective of this study is: To assess the virologic effect of changing enfuvirtide to MK-0518(raltegravir) in human immunodeficiency virus type 1(HIV-1) infected patients who have an undetectable level of serum human immunodeficiency virus(HIV) (< 75 copies/ml by branch deoxyribonucleic acid (bDNA) assay, < 50 copies/ml by Ultrasensitive Polymerase Chain Reaction(PCR) assay) on their current HIV medication regimen. Hypothesis: HIV-1 infected individuals well controlled on an enfuvirtide containing regimen with HIV RNA levels below limits of quantification can safely have the investigational integrase inhibitor, MK-0518 substituted for enfuvirtide without loss of virologic suppression.

Clinical Details

Official title: Virologic Outcomes of Changing Enfuvirtide to Raltegravir in HIV-1 Patients Well Controlled on an Enfuvirtide Based Regimen

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Number of Patients With Undetectable Human Immunodeficiency Virus (HIV) Viral Load at Week 24.

Secondary outcome: Average Change in Cluster of Differentiation 4(CD4) Cell Count From Baseline at Week 24

Detailed description: Human immunodeficiency virus type 1(HIV-1) infected patients who have had an undetectable viral load on an enfuvirtide containing regimen at the Kaiser Permanente Hayward, Los Angeles, San Francisco, and Santa Clara Medical Centers will be enrolled. Patients will receive open label MK-0518 (raltegravir) 400mg orally twice a day as substitution for enfuvirtide for 24 weeks.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients must meet all of the following inclusion criteria to be eligible for

participation in this study. 1. Subject is ≥ 18 years of age and able to understand and willing to sign a written informed consent form, which must be obtained prior to initiation of the study. 2. Documented laboratory diagnosis of HIV-1 infection (positive Enzyme-linked immunosorbent assay (ELISA) HIV-1 antibody test confirmed by western blot, p24 assay, HIV-1 RNA, or culture). 3. Have documented plasma HIV-1 RNA level(s) of < 75 copies/ml by branched deoxyribonucleic acid(bDNA) assay, or < 50 copies/ml by Ultrasensitive Polymerase Chain Reaction(PCR) for at least 6 months prior to screening visit. 4. Currently receiving a stable antiretroviral regimen consisting of enfuvirtide plus at least 2 other antiretrovirals for at least 6 months. 5. Negative serum pregnancy test (females of childbearing potential only) and are willing to use an adequate method of contraception throughout the duration of the study. Exclusion Criteria:

- Patients who meet any of the following exclusion criteria are not to be enrolled in

this study. 1. Any prior therapy with MK-0518 or any other HIV-1 integrase inhibitor. 2. Any HIV-1 viral load > 75 copies/ml by bDNA assay, or > 50 copies/ml by Ultrasensitive PCR assay in the 6 months prior to screening visit (A single "blip" of HIV-1 viral load >75 copies but <400 copies by bDNA assay, or >50 copies but <400 copies by Ultrasensitive PCR assay in the six months prior to screening visit with at least one subsequent HIV-1 viral load below the limit of detection will be accepted.) 3. Any previous known hypersensitivity to components of the study drug formulation. 4. Weight < 40 kilograms. 5. Patient requires or is anticipated to require any of the prohibited medications noted in the protocol. 6. Acute therapy for serious illness (in the opinion of the investigator) within 14 days prior to study entry unless the subject has completed ≥ 7 days of therapy and is considered clinically stable by the investigator. 7. Any condition which, in the opinion of the investigator, would compromise the subject's ability to participate in the study. 8. Any active opportunistic infections or Centers for Disease Control and Prevention (CDC) Category C conditions (with the exception of stable cutaneous Kaposi's Sarcoma and wasting syndrome due to HIV infection). 9. Any malignancy requiring chemotherapy. 10. Subject has any of the following laboratory results at screening: Hemoglobin < 8. 0 gr/dl Absolute neutrophil count < 750 cells/ml Platelet count < 40,000 Creatinine > 2. 0 or calculated creatinine clearance < 40 ml/min 11. Female patient who is pregnant or breast-feeding, or expecting to conceive or donate eggs during the study. Male patient who is planning to impregnate or provide sperm donation during the study.

Locations and Contacts

Kaiser Anaheim, Anaheim, California 92807, United States

Kaiser Hayward, Hayward, California 95454, United States

Kaiser Los Angeles, Los Angeles, California 90027, United States

Kaiser West Los Angeles, Los Angeles, California 90034, United States

Kaiser Panorama City, Panorama City, California 91402, United States

Kaiser San Francisco, San Francisco, California 94118, United States

Kaiser Santa Clara, Santa Clara, California 95051, United States

Kaiser Santa Clarita, Santa Clarita, California 91355, United States

Additional Information

Starting date: September 2007
Last updated: March 10, 2015

Page last updated: August 23, 2015

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