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Bevacizumab and Endothelium Dependent Vasodilation

Information source: Radboud University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension; Cancer; Endothelial Dysfunction

Intervention: Acetylcholine (Drug); Nitroprusside (Drug); Bevacizumab (Drug)

Phase: N/A

Status: Completed

Sponsored by: Radboud University

Summary

The introduction of angiogenesis inhibitors has remarkably improved treatment of patients with several types of cancer. One of the most reported side effects of angiogenesis inhibitors is hypertension. In patients treated with bevacizumab, a monoclonal antibody against vascular endothelial growth factor, hypertension had an overall incidence up to 32%. The increase in blood pressure occurs early in treatment. The etiology of hypertension caused by treatment with angiogenesis inhibitors is unclear. Understanding the pathogenesis of this side effect is essential for optimal treatment with this class of drugs. The primary objective is to explore the effect of bevacizumab infusion on endothelium-dependent vasodilation of forearm resistance arteries.

Clinical Details

Official title: Bevacizumab and Endothelium Dependent Vasodilation

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome: Vasomotor response assessed by venous occlusion strain gauge plethysmography

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Male.

Criteria:

Inclusion Criteria: 1. Age 18-50 years old 2. Male 3. Results of serum glucose, lipids and creatinine should be within the laboratory's reference ranges. 4. Subject is able and willing to sign the Informed Consent Form prior to screening evaluations. Exclusion Criteria: 1. Documented history of sensitivity/idiosyncrasy to medicinal products or excipients. 2. History of or current abuse of drugs, alcohol or solvents. 3. History of malignant disease. 4. First degree relatives with a history of cancer before the age of 50 5. First degree relatives with a history of premature cardiovascular disease before the age of 50 6. Current use of medication. 7. Clinical evidence of cardiac or pulmonary disease 8. Hypertension ( systole >140mmHG, diastole >90mmHg) 9. Diabetes mellitus 10. Smoking 11. Any clinically relevant abnormality on ECG. 12. A history of thrombosis or first degree family members with a history of recurrent thrombosis 13. Inability to understand the nature and extent of the trial and the procedures required. 14. Previous participation in a study with bevacizumab

Locations and Contacts

Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Additional Information

Starting date: June 2010
Last updated: January 8, 2013

Page last updated: August 23, 2015

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