DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass

Information source: Mayo Clinic
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Hemorrhage

Intervention: Heparin (Drug); HH or high heparin (Drug); heparin concentration HC (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Mayo Clinic

Official(s) and/or principal investigator(s):
William Oliver, MD, Principal Investigator, Affiliation: Mayo Clinic

Summary

Study has been completed and is in the data analysis and manuscript writing phase of the project.

Clinical Details

Official title: Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: measure blood loss

Secondary outcome: transfusion requirements

Eligibility

Minimum age: 18 Years. Maximum age: 90 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Adult male and non-pregnant female patients scheduled for elective cardiac surgery

requiring CPB will be eligible for enrollment. Exclusion Criteria:

- Age less than 18 or greater than 90 years; emergency surgery

- Circulatory arrest

- Combined non-cardiac procedures such as carotid endarterectomy

- Congenital heart repair

- Off-CPB coronary artery bypass grafting (CABG)

- Clotting disorder

- Fibrinolytic agents (e. g. streptokinase), severe hepatic disease

- Aprotinin use

- Cooling < 28 degrees C during CPB

- Dialysis dependent renal failure; and

- Platelet receptor GP3a/2b antagonists medication received within 48 hours of surgery.

Patients that are not receiving tranexamic acid (TA) intraoperatively will be excluded.

Locations and Contacts

Mayo Clinic, Rochester, Minnesota 55901, United States
Additional Information

Starting date: June 2001
Last updated: October 14, 2009

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017