Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.

Condition(s) targeted: Incretin Action; Obesity

Intervention: GLP-1 infusion (Other); Glucagon infusion (Other); Oxyntomodulin infusion (Other); GLP-1 and glucagon infusion (Other); Placebo (Other)

Phase: N/A

Status: Completed

Sponsored by: University Hospital, Gentofte, Copenhagen

Official(s) and/or principal investigator(s):
Jonatan I Bagger, MD, Principal Investigator, Affiliation: Gentofte University Hospital, University of Copenhagen

Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss. Therefore we want to investigate mechanistic relations between the three hormones.

Study design: N/A

Primary outcome:

Gastric emptying

Satiety

Hunger

basal energy expenditure

Secondary outcome:

GLP-1

Oxyntomodulin

Glucagon

GIP

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Normal fasting plasma glucose

- Normal glucose tolerance

- Normal haemoglobin levels

- Informed content

Exclusion Criteria:

- Diabetes

- Pre diabetes (impaired glucose tolerance or impaired fasting glucose)

- 1st degree relatives with diabetes

- Obesity (BMI > 30)

- Inflammatory bowels disease

- Bowels surgery

- Nephropathy

- Liver disease

- Medication which cannot be on hold for 24h

Gentofte University Hospital, Hellerup 2900, Denmark

Starting date: October 2010
Last updated: December 9, 2013