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Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.

Information source: University Hospital, Gentofte, Copenhagen
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Incretin Action; Obesity

Intervention: GLP-1 infusion (Other); Glucagon infusion (Other); Oxyntomodulin infusion (Other); GLP-1 and glucagon infusion (Other); Placebo (Other)

Phase: N/A

Status: Completed

Sponsored by: University Hospital, Gentofte, Copenhagen

Official(s) and/or principal investigator(s):
Jonatan I Bagger, MD, Principal Investigator, Affiliation: Gentofte University Hospital, University of Copenhagen


Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss. Therefore we want to investigate mechanistic relations between the three hormones.

Clinical Details

Study design: N/A

Primary outcome:

Gastric emptying



basal energy expenditure

Secondary outcome:






Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Male.


Inclusion Criteria:

- Normal fasting plasma glucose

- Normal glucose tolerance

- Normal haemoglobin levels

- Informed content

Exclusion Criteria:

- Diabetes

- Pre diabetes (impaired glucose tolerance or impaired fasting glucose)

- 1st degree relatives with diabetes

- Obesity (BMI > 30)

- Inflammatory bowels disease

- Bowels surgery

- Nephropathy

- Liver disease

- Medication which cannot be on hold for 24h

Locations and Contacts

Gentofte University Hospital, Hellerup 2900, Denmark
Additional Information

Starting date: October 2010
Last updated: December 9, 2013

Page last updated: August 23, 2015

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