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Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist

Information source: Universitair Ziekenhuis Brussel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Reproductive Endocrinology; Fertility; Optimal Stimulation Protocol

Intervention: GnRH agonist (Drug); GnRH antagonist (Drug); hP-hMG (Drug); Human chorionic gonadotropin (Drug); Progesterone (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Universitair Ziekenhuis Brussel

Summary

The aim of our study is to define the optimal ovarian stimulation protocol concerning PGD and for this reason we plan a randomized controlled trial (RCT) comparing gonadotropin-releasing hormone (GnRH) agonist protocol versus GnRH antagonist protocol. The follicle stimulating hormone (FSH) preparation in both arms will be highly purified FSH (Menopur®).

Clinical Details

Official title: The Effect of the Type of Ovarian Stimulation Protocol on PGD Results: a Prospective Randomised Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: Number of day 3 embryos for biopsy available

Secondary outcome:

Number of mature cumulus-oocyte complexes

clinical pregnancy rate

Detailed description: Patients will be randomized at the outpatient clinic in two groups.

Eligibility

Minimum age: 18 Years. Maximum age: 39 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- ≤ 39 years the day of oocyte retrieval

- BMI ≤ 29

- cycle rank 1

- menstrual cycle 25-36 days

- PGD or preimplantation genetic screening (PGS) requested

- ICSI

- Single embryo transfer (SET) on day 5

Exclusion Criteria:

- Polycystic Ovary Syndrome (PCOS) (according Rotterdam criteria)

- Hormonal disturbances

- Endometriosis grade III and IV

Locations and Contacts

Centre for Reproductive Medicine, Brussels 1090, Belgium
Additional Information

Starting date: September 2010
Last updated: June 27, 2013

Page last updated: August 23, 2015

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