Preimplantation Genetic Diagnosis (PGD) With Gonadotropin-releasing Hormone (GnRH) Agonist Versus Antagonist
Information source: Universitair Ziekenhuis Brussel
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Reproductive Endocrinology; Fertility; Optimal Stimulation Protocol
Intervention: GnRH agonist (Drug); GnRH antagonist (Drug); hP-hMG (Drug); Human chorionic gonadotropin (Drug); Progesterone (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Universitair Ziekenhuis Brussel
Summary
The aim of our study is to define the optimal ovarian stimulation protocol concerning PGD
and for this reason we plan a randomized controlled trial (RCT) comparing
gonadotropin-releasing hormone (GnRH) agonist protocol versus GnRH antagonist protocol. The
follicle stimulating hormone (FSH) preparation in both arms will be highly purified FSH
(Menopur®).
Clinical Details
Official title: The Effect of the Type of Ovarian Stimulation Protocol on PGD Results: a Prospective Randomised Trial
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Primary outcome: Number of day 3 embryos for biopsy available
Secondary outcome: Number of mature cumulus-oocyte complexesclinical pregnancy rate
Detailed description:
Patients will be randomized at the outpatient clinic in two groups.
Eligibility
Minimum age: 18 Years.
Maximum age: 39 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- ≤ 39 years the day of oocyte retrieval
- BMI ≤ 29
- cycle rank 1
- menstrual cycle 25-36 days
- PGD or preimplantation genetic screening (PGS) requested
- ICSI
- Single embryo transfer (SET) on day 5
Exclusion Criteria:
- Polycystic Ovary Syndrome (PCOS) (according Rotterdam criteria)
- Hormonal disturbances
- Endometriosis grade III and IV
Locations and Contacts
Centre for Reproductive Medicine, Brussels 1090, Belgium
Additional Information
Starting date: September 2010
Last updated: June 27, 2013
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