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Impact of Exercise Training on Endothelial Function in CAD

Information source: University of Leipzig
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Artery Disease

Intervention: Exercise Training (Behavioral)

Phase: Phase 2

Status: Recruiting

Sponsored by: University of Leipzig

Official(s) and/or principal investigator(s):
Rainer P Hambrecht, MD, Principal Investigator, Affiliation: University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology

Overall contact:
Rainer P Hambrecht, MD, Phone: ++49-341 865, Ext: 1428, Email: hamr@medizin.uni-leipzig.de

Summary

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention. Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.

Clinical Details

Official title: Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Educational/Counseling/Training

Primary outcome: Endothelial function

Detailed description: A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle. Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- stable CAD

- male gender

Exclusion Criteria:

- insulin-dependent diabetes mellitus

- significant valvular heart disease

- smoking

- exercise-induced myocardial ischemia

- conditions prohibiting exercise training

Locations and Contacts

Rainer P Hambrecht, MD, Phone: ++49-341 865, Ext: 1428, Email: hamr@medizin.uni-leipzig.de

University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology, Leipzig, Saxony 04289, Germany; Recruiting
Rainer P Hambrecht, MD, Phone: ++49-341-865, Ext: 1428, Email: hamr@medizin.uni-leipzig.de
Sandra Erbs, MD, Phone: ++49-341-865, Ext: 1428, Email: Sandra.Erbs@medizin.uni-leipzig.de
Rainer P Hambrecht, MD, Principal Investigator
Additional Information

Starting date: January 2001
Last updated: September 11, 2005

Page last updated: August 23, 2015

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