Impact of Exercise Training on Endothelial Function in CAD
Information source: University of Leipzig
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Artery Disease
Intervention: Exercise Training (Behavioral)
Phase: Phase 2
Status: Recruiting
Sponsored by: University of Leipzig Official(s) and/or principal investigator(s): Rainer P Hambrecht, MD, Principal Investigator, Affiliation: University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
Overall contact: Rainer P Hambrecht, MD, Phone: ++49-341 865, Ext: 1428, Email: hamr@medizin.uni-leipzig.de
Summary
Bradykinin has been identified to contribute to the release of nitric oxide (NO),
prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is
finally promoting a vasodilatory respone. Regular physical exercise training results in an
improvement of endothelial function in patients with CAD. These positive effects were
partially attributed to an increased expression of endothelial NO synthase (eNOS) and
cyclooxygenase (COX) as a result of the training intervention.
Aim of this trial is therefore to determine, whether the training-induced correction of
endothelial dysfunction is also bradykinin-dependent.
Clinical Details
Official title: Impact of Exercise Training on Bradykinin-Mediated Endothelial Function in Patients With Coronary Artery Disease
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Educational/Counseling/Training
Primary outcome: Endothelial function
Detailed description:
A total of 20 patients with stable coronary artery disease are prospectively randomized to 4
weeks of exercise training or sedentary lifestyle.
Endothelial function of the radial artery is determined by a high-resolution A-mode
ultrasound.
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- stable CAD
- male gender
Exclusion Criteria:
- insulin-dependent diabetes mellitus
- significant valvular heart disease
- smoking
- exercise-induced myocardial ischemia
- conditions prohibiting exercise training
Locations and Contacts
Rainer P Hambrecht, MD, Phone: ++49-341 865, Ext: 1428, Email: hamr@medizin.uni-leipzig.de
University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology, Leipzig, Saxony 04289, Germany; Recruiting Rainer P Hambrecht, MD, Phone: ++49-341-865, Ext: 1428, Email: hamr@medizin.uni-leipzig.de Sandra Erbs, MD, Phone: ++49-341-865, Ext: 1428, Email: Sandra.Erbs@medizin.uni-leipzig.de Rainer P Hambrecht, MD, Principal Investigator
Additional Information
Starting date: January 2001
Last updated: September 11, 2005
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