Intrathecal Morphine in Knee Arthroplasty

Condition(s) targeted: Pain, Postoperative; Arthroplasty, Replacement, Knee

Intervention: intra thecal morphine (Drug); intra thecal morphine (Drug); intra thecal morphine (Drug)

Phase: N/A

Status: Completed

Sponsored by: University College Hospital Galway

Official(s) and/or principal investigator(s):
Patrick D Hassett, MD, Principal Investigator, Affiliation: Department of Anaesthesia, UCHG
John Laffey, MD, Study Chair, Affiliation: Department of Anaesthesia,UCHG
Brian Kinirons, MD, Study Director, Affiliation: Dept of Anaesthesia , UCHG

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement. We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Official title: Determination of the Efficacy and Side-Effect Profile of Lower Doses of Intrathecal Morphine in Patients Undergoing Total Knee Arthroplasty

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: pain

Secondary outcome:

nausea and vomiting

pruritus

sedation

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients for elective total knee arthroplasty

Exclusion Criteria:

- No contraindication to spinal

- No allergy to morphine, rescue analgesia or anti-emesis treatment.

Starting date: July 2003
Last updated: June 9, 2008