Interaction of Apelin and Angiotensin in the Human Forearm Circulation
Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Heart Disease; Vasodilation
Intervention: Angiotensin II (Drug); Noradrenaline infusion (Drug)
Phase: N/A
Status: Completed
Sponsored by: University of Edinburgh Official(s) and/or principal investigator(s): Gareth D Barnes, MBChB, Principal Investigator, Affiliation: University of Edinburgh
Summary
The apelin-APJ system is a relatively new discovery. It has generated interest in part due
to it's apparent ability to counteract the renin-angiotensin system, which is frequently
overactive in many cardiovascular disease.
Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence
blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an
infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the
diameter of blood vessels.
Clinical Details
Official title: Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
Primary outcome: Change in angiotensin II mediated vasoconstriction
Secondary outcome: Changes in relevant neurohumoral hormones in response to apelin infusion
Eligibility
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- > 18 years old
- Healthy volunteers
Exclusion Criteria:
- Lack of informed consent
- Age < 18 years,
- Current involvement in other research studies,
- Systolic blood pressure >190 mmHg or <100 mmHg
- Malignant arrhythmias
- Renal or hepatic failure
- Haemodynamically significant aortic stenosis
- Severe or significant co morbidity
- Women of childbearing potential.
- Any regular medication
- Previous history of any cardiovascular disease
Locations and Contacts
Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc, Edinburgh EH16 4SA, United Kingdom
Additional Information
Starting date: May 2009
Last updated: August 9, 2010
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