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Loop Diuretics Administration and Acute Heart Failure

Information source: University of Siena
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acute Heart Failure

Intervention: furosemide infusion (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: University of Siena

Overall contact:
Alberto Palazzuoli, MD, Phone: +39577585363, Email: palazzuoli2@unisi.it

Summary

Intravenous loop diuretics is the therapy most commonly used to treat pulmonary congestion and systemic fluid overload. In theory, continuous infusion should allow for a more consistent diuresis, avoiding the sodium reabsorption in the distal tubule as well as the neurohormonal activation. This should lead to renal function improvement and BNP decrease.

Clinical Details

Official title: Continuous Versus Intermittent Loop Diuretics Infusion Dosing in Acute Heart Failure: Effects on Renal Function, Outcome and BNP Levels

Study design: Observational Model: Cohort, Time Perspective: Retrospective

Primary outcome: evaluation of renal function and BNP levels during loop diuretic infusion

Secondary outcome: length of hospitalization and evaluation of cardiac events in the two groups

Eligibility

Minimum age: 40 Years. Maximum age: 90 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients took part in the random sample selection if they met the diagnostic criteria

for acute decompensated HF.

- They also displayed impaired ejection fraction (LVEF <45%) with cardiac

dilatation and pulmonary hypertension Exclusion Criteria:

- Patients were excluded if they had received more than 2 IV doses of furosemide or any

continuous infusion of furosemide 1 month before randomization

- If they had end-stage renal disease or the need for renal replacement therapy,

isolated diastolic dysfunction

- Recent myocardial infarction

Locations and Contacts

Alberto Palazzuoli, MD, Phone: +39577585363, Email: palazzuoli2@unisi.it

Department of Internal Medicine, Cardiology Section Center, Siena, 53100, Italy; Recruiting
Alberto Palazzuoli, MD, Phone: +39577585363, Email: palazzuoli2@unisi.it
Alberto Palazzuoli, MD, Principal Investigator
Additional Information

Starting date: April 2010
Last updated: September 23, 2011

Page last updated: August 20, 2015

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