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Clinical Trial Comparing Catheter Lock Solutions TaurolockTMHep 100 and Heparin 100 IE/ml.

Information source: Rigshospitalet, Denmark
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Catheter-related Bloodstream Infection (CRBSI) Nos

Intervention: TaurolockTMHep100 (Device); Heparin 100 IE/ml (Device)

Phase: Phase 4

Status: Active, not recruiting

Sponsored by: Palle Bekker Jeppesen

Official(s) and/or principal investigator(s):
Palle B Jeppesen, Ass. Prof., Principal Investigator, Affiliation: Medicinsk Gastroenterologisk klinik CA, 2121, Abdominal centret, Rigshospitalet

Summary

The purpose of the investigation is to compare two catheter lock solutions (TaurolockTMHep100 and Heparin 100 IE/ml), on the occurence of catheter related blood stream infection, in patients with intestinal failure and a central venous access device for home parenteral nutrition.

Clinical Details

Official title: A Double Blinded, Randomized, Controlled Investigation of Taurolidine-citrate/Heparin Catheter Lock Solution Versus Heparin in Patients on Home Parenteral Nutrition With Previously Proven High Risk of Catheter Related Blood Stream Infections.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Mean number of catheter related blood stream infections(CRBSI)/ 1000 catheter days in each group

Secondary outcome:

Median time to a catheter related blood stream infection(CRBSI) in each group.

Number and frequency of catheter removals due to catheter-related infections in each group

Number and frequency of exit site infections in each group

Median time to catheter removal due to catheter-related infections in each group

Number and frequency of catheter occlusions in each group

Number and frequency of patients having serious adverse event and adverse event in each group

Detailed description: Patients with long-term intestinal failure are dependent on Home Parenteral Nutrition(HPN) delivered through a central venous access device(CVAD), placed as a subcutaneous tunneled catheter(Broviac). Catheter Related Blood Stream Infections(CRBSI) is a frequent complication leading to increased morbidity, hospital admissions, cost, and risk of repeated replacement of their tunneled catheter. The infections often originate from contamination of the catheter hub, and growth of microorganisms on the inner lumen of the catheter imbedded in a biofilm. To prevent infections good hygiene guidelines and the use of a catheter lock solution is applied. The primary objective is to compare two catheter lock solutions, TaurolockTMHep100 and Heparin 100 IE/ml, on the occurence of CRBSI. The secondary objectives are to compare the two devices according to other efficacy parameters, time to infection, cost and resource utility, tolerability and safety. Patients with a prior high risk of CRBSI will be included. Patients will instill the solution in their CVAD after each infusion of HPN, varying between minimum twice per week to once daily, depending on their individual HPN programme. Before the blinded randomization the patients will be paired according to gender, age and prior infection risk. Duration of the instillation will be 24 month or until outcome(CRBSI) accure.

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with long-term intestinal failure who will receive PS at least 2 times /week

over a subcutaneously tunneled single-lumen CVC (Hickman/Broviac) for at least one year.

- Estimated life expectancy ≥1 year

- Male or female patient aged 18 - 80 years

- Patient is fully able to understand the nature of the proposed intervention and gives

written informed consent before entering the trial. Exclusion Criteria: Patients who:

- can not be expected to comply with the trial plan (e. g. substance abuse, mental

condition)

- has significant cardiovascular disease such as unstable angina, recent acute

myocardial infarction or recent cerebral vascular accident (within 6 weeks); a cardiac rhythm which in the investigators judgment may result in significant hemodynamic effects

- has a known hypersensitivity/allergy to TauroLockTMHep 100 or heparin and/or their

excipients.

- is pregnant, lactating, or nursing

- has abnormal blood coagulation due to primary disease or due to treatment with

anticoagulants (warfarin/phenprocoumon, unfractionated heparin, low- molecular heparin), with the clinical blood tests INR and APTT, outside the intervals given below, at the time of inclusion. Patients with unfractionated Heparin 100 IE/ml used as a catheter lock, do not need to have APTT tested before enrollment. Patients treated with Low-Molecular Heparin, needs control of INR, thrombocytes and plasma-antifactor Xa, and If the patient has increased bleeding risk judge by disease and clinical blood tests, the patient can´t be included in the trial. INR 0. 9-3. 0 (warfarin/ phenprocoumon) APTT needs to be in the range 25-100 seconds (Unfractionated Heparin treatment) Plasma-antifactor Xa( outside recommended intervals (pro. medicin. dk), which are dependent on administration form and number of daily administrations ). Thrombocytes 100- 600 x109/L

- Patients with a new catheter-related thrombosis in the last 3 months prior to

inclusion.

- has received an investigational drug within 30 days of trial entry

- has received a TauroLockTMHep 100 solution previously

- has an antibiotic coated, silver impregnated or antimicrobial cuff catheter

- has compromised skin integrity, including any infection at the insertion site

Locations and Contacts

Rigshospitalet, abdominalcentret, Medicinsk Gastroenterologisk klinik CA, 2121, Copenhagen 2100, Denmark
Additional Information

Starting date: October 2013
Last updated: June 19, 2014

Page last updated: August 23, 2015

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