Patients with cystic fibrosis (CF) suffer from chronic infections of the lower respiratory
tract that can be caused by one or multiple bacteria, including Pseudomonas aeruginosa,
which has been particularly problematic to eradicate and been implicated as the major cause
of morbidity and mortality in CF patients. Aerosol delivery of antibiotics directly to the
lung increases the local concentrations of antibiotic at the site of infection resulting in
improved antimicrobial effects compared to systemic administration. Bacterial resistance to
current aerosol antibiotic treatments indicate a need for improved therapies to treat CF
patients with pulmonary infections caused by multi-drug resistant Pseudomonas aeruginosa and
other bacteria. High concentrations of MP-376 delivered directly to the lung are projected
to have antimicrobial effects on even the most resistant organisms.
Minimum age: 12 Years.
Maximum age: N/A.
Gender(s): Both.
Hôpital Pellegrin Enfants - CHU Bordeaux, Bordeaux 33076, France
CRCM adultes et enfants Service des maladies respiratoires et pédiatrie 1 CHU- Arnaud de Villeneuve, Montpellier 34295, France
Hôpital Cochin, Paris 75014, France
Hôpital Necker-Enfants Malades, Paris 75743, France
Hôpital Haut-Lévêque CHU de Bordeaux, Pessac 33604, France
CRCM adulte Hôpital Larrey-CHU de Toulouse, Toulouse 31059, France
Charité Campus Virchow-Klinikum, Berlin, Germany
Universitätskinderklinik Dresden Mukoviszidose-Ambulanz, Dresden, Germany
Universitätsklinikum Essen, Essen, Germany
Katharina-Kasper Kliniken GmbH St. Elisabethen-Krankenhaus Medizinische Klinik, Frankfurt, Germany
Universitätsklinikum Frankfurt, Frankfurt, Germany
Universitätsklinik Gießen und Marburg GmbH Zentrum für Kinderheilkunde und Jugendmedizin, Gieben, Germany
Kinderärztliche Gemeinschaftspraxis Dr. H. E. Heuer, Dr. C. Runge, W. Sextro, Hamburg, Germany
Universitätsklinikum Kiel, Kiel, Germany
Ludwig-Maximilians Universität Klinikum Innenstadt, Munchen, Germany
Dr. von Haunersches Kinderspital der Universität München Christiane Herzog Ambulanz, Munich, Germany
Universitätsklinik für Kinder- und Jugendmedizin, Tubingen, Germany
Cork University Hospital, Cork, Ireland
Beaumont Hospital, Dublin, Ireland
National Children's Hospital Tallaght, Dublin, Ireland
St. Vincent's University Hospital, Dublin, Ireland
Rambam Medical Center, Haifa 31096, Israel
Hadassah Medical Center Mount Scopus, Jerusalem 91240, Israel
Schneider Childrens Medical Center of Israel, Petah Tikva 49202, Israel
Safra Childrens Hospital, Sheba Medical Center, Ramat Gan 52621, Israel
Belfast City Hospital, Belfast BT9 7AB, United Kingdom
Birmingham Heartlands Hospital, Birmingham B95SS, United Kingdom
Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, United Kingdom
St James's University Hospital, Leeds LS97TF, United Kingdom
King's College Hospital, London SE59RS, United Kingdom
University Hospital Llandough, Penarth, Penarth CF64 2XX, United Kingdom
Mobile, Alabama 36608, United States
Anchorage, Alaska 99508, United States
Phoenix, Arizona 85016, United States
Tucson, Arizona 85724, United States
Little Rock, Arkansas 72202, United States
La Jolla, California 92037, United States
Long Beach, California 90806, United States
Los Angeles, California 90033, United States
Childrens Hospital, Los Angeles, California 90027, United States
Oakland, California 94611, United States
Orange, California 92868, United States
Palo Alto, California 94304, United States
Sacramento, California 95817, United States
San Diego, California 92103, United States
San Diego, California 92123, United States
San Francisco, California 94115, United States
Aurora, Colorado 80045, United States
Denver, Colorado 80206, United States
Hartford, Connecticut 06106, United States
New Haven, Connecticut 65020, United States
Wilmington, Delaware 19803, United States
Gainesville, Florida 32610, United States
Jacksonville, Florida 32207, United States
Miami, Florida 33136, United States
Orlando, Florida 32801, United States
St. Petersburg, Florida 33701, United States
Tampa, Florida 33606, United States
Atlanta, Georgia 30322, United States
Boise, Idaho 83712, United States
Chicago, Illinois 60614, United States
Chicago, Illinois 60637, United States
Glenview, Illinois 60025, United States
Niles, Illinois 60714, United States
Peoria, Illinois 61637, United States
Indianapolis, Indiana 43202, United States
Indianapolis, Indiana 46202, United States
Wichita, Kansas 67214, United States
Lexington, Kentucky 40536, United States
Louisville, Kentucky 40202, United States
Portland, Maine 04102, United States
Baltimore, Maryland 21287, United States
Boston, Massachusetts 02114, United States
Boston, Massachusetts 02115, United States
Worcester, Massachusetts 01655, United States
Ann Arbor, Michigan 48109, United States
Detroit, Michigan 48201, United States
Grand Rapids, Michigan 49503, United States
Minneapolis, Minnesota 55455, United States
Jackson, Mississippi 39216, United States
Columbia, Missouri 65212, United States
Kansas City, Missouri 64108, United States
St. Louis, Missouri 63110, United States
Omaha, Nebraska 68105, United States
Las Vegas, Nevada 89107, United States
Lebanon, New Hampshire 03756, United States
Manchester, New Hampshire 03104, United States
Livingston, New Jersey 07039, United States
Morristown, New Jersey 07962, United States
Albuquerque, New Mexico 87131, United States
Albany, New York 12208, United States
Albany Medical College #2, Albany, New York 12208, United States
New Hyde Park, New York 11042, United States
New York, New York 10003, United States
New York, New York 10032, United States
Syracuse, New York 13210, United States
Valhalla, New York 10595, United States
Durham, North Carolina 27710, United States
Akron, Ohio 44308, United States
Cincinnati, Ohio 45229, United States
Columbus, Ohio 43205, United States
Dayton, Ohio 45404, United States
Toledo, Ohio 43606, United States
Oklahoma City, Oklahoma 73112, United States
Oklahoma CF Center, Oklahoma City, Oklahoma 73104, United States
Hershey, Pennsylvania 17033, United States
Philadelphia, Pennsylvania 19102, United States
Philadelphia, Pennsylvania 19104, United States
Pittsburgh, Pennsylvania 15224, United States
Charleston, South Carolina 29425, United States
Columbia, South Carolina 29203, United States
Sioux Falls, South Dakota 57117, United States
Memphis, Tennessee 38105, United States
Nashville, Tennessee 37232, United States
Austin, Texas 78723, United States
Dallas, Texas 75390, United States
Fort Worth, Texas 76104, United States
Houston, Texas 77030, United States
San Antonio, Texas 78212, United States
Tyler, Texas 75708, United States
Salt Lake City, Utah 84132, United States
Colchester, Vermont 05446, United States
Charlottesville, Virginia 22908, United States
Norfolk, Virginia 23507, United States
Portsmouth, Virginia 23708, United States
Richmond, Virginia 23298, United States
Seattle, Washington 98105, United States
Morgantown, West Virginia 26506, United States
Milwaukee, Wisconsin 53201, United States
Milwaukee, Wisconsin 53266, United States