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Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome

Information source: University of California, Davis
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Fragile X-Associated Tremor/Ataxia Syndrome; Fragile X Premutation Carriers

Intervention: Memantine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: University of California, Davis

Official(s) and/or principal investigator(s):
Randi J Hagerman, MD, Principal Investigator, Affiliation: University of California, Davis

Overall contact:
Jennifer B Cogswell, Phone: 916-703-0331, Email: jennifer.cogswell@ucdmc.ucdavis.edu


The purpose of this study is to determine if memantine is effective in treating symptoms of Fragile X-associated Tremor Ataxia Syndrome.

Clinical Details

Official title: Characterization and Treatment of CNS Abnormalities in Premutation Carriers: A Double-Blind Placebo-Controlled Trial of Memantine

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Improvement in neurocognitive functioning

Secondary outcome: Improvement in Cognitive ERP Deficits


Minimum age: 30 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Fragile X premutation carrier (CGG repeat 55-200)with neurological symptoms

Exclusion Criteria:

- Previous reaction to memantine

Locations and Contacts

Jennifer B Cogswell, Phone: 916-703-0331, Email: jennifer.cogswell@ucdmc.ucdavis.edu

UC Davis MIND Institute, Sacramento, California 95817, United States; Recruiting
Jennifer B Cogswell, Phone: 916-703-0331, Email: jennifer.cogswell@ucdmc.ucdavis.edu
Louise Gane, Phone: 916-703-0238, Email: louise.gane@ucdmc.ucdavis.edu
Randi J Hagerman, MD, Principal Investigator

University of Colorado Health Sciences Center, Aurora, Colorado 80045, United States; Recruiting
Maureen Leehey, MD, Principal Investigator

Additional Information

Starting date: September 2007
Last updated: June 25, 2010

Page last updated: August 23, 2015

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