Efficacy and Safety of L Arginine to Prevent Preeclampsia
Information source: Hospital Civil Juan I. Menchaca
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Preeclampsia
Intervention: L arginine (Dietary Supplement)
Phase: Phase 3
Status: Completed
Sponsored by: Hospital Civil Juan I. Menchaca Official(s) and/or principal investigator(s): Guadalupe Panduro, Ph, Study Chair, Affiliation: Hospital Civil Juan I. Menchaca
Summary
Randomized double-blind controled clinical trial to assess the efficacy and safety of
L-arginine to prevent preeclampsia.
applied to pregnant women with risk factors for preeclampsia. the main result was the
development of preeclampsia as well as side effects to taking l arginine besides perinatal
outcomes
Clinical Details
Official title: Efficacy and Safety of L Arginine to Prevent Preeclampsia in High Risk Pregnancies
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention
Primary outcome: efficacy of L arginine to prevent preeclampsia
Secondary outcome: perinatal outcomesafety of L arginine
Detailed description:
Two groups were formed. one received L arginine 3 grams orally at day from the 20th week of
pregnancy. the other group received placebo.
Each three weeks were evaluated in search of high blood pressure and proteinuria.
The follow-up was until the end of pregnancy and two weeks after this
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- one or more risk factors for developing preeclampsia (nulliparous, previous history
of preeclampsia, chronic hypertension, BMI ≥30)
Exclusion Criteria:
- pregnant women carriers of chronic renal failure
- pre gestational diabetes
- multiple pregnancy and were removed for some reason they received medication that
would interfere with the interpretation of results (aspirin)
Locations and Contacts
Panduro Baron J Guadalupe, Guadalajara, Jalisco 44340, Mexico
Additional Information
Related publications: Johal T, Lees CC, Everett TR, Wilkinson IB. The nitric oxide pathway and possible therapeutic options in pre-eclampsia. Br J Clin Pharmacol. 2014 Aug;78(2):244-57. doi: 10.1111/bcp.12301. Review.
Starting date: August 2010
Last updated: February 9, 2015
|