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Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-Blind, Placebo Controlled Trial

Information source: University of Texas Southwestern Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Vasomotor Rhinitis

Intervention: esomeprazole (Drug); placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Texas Southwestern Medical Center

Official(s) and/or principal investigator(s):
David A Khan, MD, Principal Investigator, Affiliation: Department of Allergy and Immunology, UT Southwestern

Summary

The purpose of this study was to see if high dose esomeprazole (40mg bid) was effective in treating non-allergic rhinitis

Clinical Details

Official title: Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-Blind, Placebo Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Nasal Symptom scores

Secondary outcome:

non-nasal symptom scores

reflux scores

quality of life scores

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- age between 18-80, symptoms of perennial rhinitis, negative epicutaneous skin testing

to a panel of common aeroallergens, and ability to speak English Exclusion Criteria:

- pregnancy or breast-feeding, evidence of positive skin tests to a common

aeroallergen, treatment with a proton pump inhibitor within the month prior to enrollment, treatment with any other anti-reflux therapy within the last month on a daily basis or within the last two weeks on an as needed basis, and other gastrointestinal disorders leading to reflux symptoms

Locations and Contacts

Clinical Trials Office, Aston Building, UT Southwestern, Dallas, Texas 75390-9016, United States
Additional Information

Starting date: June 2005
Last updated: August 29, 2008

Page last updated: August 23, 2015

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