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A Study to Determine the Improvement of the Symptoms of Benign Prostatic Hyperplasia (BPH) When Switching Subjects From Proscar to Avodart

Information source: Urologic Consultants of Southeastern PA
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Benign Prostatic Hyperplasia

Intervention: Dutasteride (Drug)

Phase: Phase 4

Status: Enrolling by invitation

Sponsored by: Urologic Consultants of Southeastern PA


Hypothesis: Dutasteride will perform better than finasteride in decreasing prostate volume, improving symptoms based on International Prostate Symptom score,and lower pvr based on the scientific information that dutasteride inhibits both Type I and II 5-alpha-reducatase vs. finasteride which only inhibits the Type II enzyme

Clinical Details

Official title: Switch Study: Are There Any Measurable Differences When Switching Patients on Finasteride Therapy to Dutasteride?

Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Laboratory parameters: including serum testosterone, DHT level and PSA

Secondary outcome:

volume measurements of TRUSP and PVR

A decrease in the AUASI


Minimum age: 50 Years. Maximum age: 80 Years. Gender(s): Male.


Inclusion Criteria:

- Male

- Age 50-80

- On finasteride for no less than 12 months

- Willing to undergo all necessary test in the 12 month evaluation

Exclusion Criteria:

- History of medication non-compliance

- Unwillingness to undergo/tolerate 2 blood draws

- Unwillingness to tolerate/undergo 2 TRUSP

Locations and Contacts

Urologic Consultants of Southeastern PA, Bala Cynwyd, Pennsylvania 19004, United States
Additional Information

Starting date: May 2008
Last updated: June 4, 2008

Page last updated: August 23, 2015

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