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Effects of Berries on Post-meal Blood Sugar

Information source: University of Eastern Finland
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Blood Glucose, Postprandial; Blood Insulin, Postprandial; Hyperglycemia

Intervention: Berries (Other); No berries (Other)

Phase: N/A

Status: Completed

Sponsored by: Marjukka Kolehmainen

Official(s) and/or principal investigator(s):
Riitta Törrönen, Dr, Principal Investigator, Affiliation: Senior Scientist


The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

Clinical Details

Official title: Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome:

Plasma glucose

Plasma insulin

Secondary outcome: Plasma free fatty acids

Detailed description: Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited. The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

- Studies 1-2: white wheat bread (starch) is consumed with several berry species

- Study 3: white wheat bread or rye bread is consumed with a mixture of berries

- Study 4: sugar (sucrose) is consumed with berries and berry nectars

- Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries

and berry nectar.


Minimum age: 25 Years. Maximum age: 69 Years. Gender(s): Both.


Inclusion Criteria:

- BMI 20-28 kg/m2

- normal fasting plasma glucose

Exclusion Criteria:

- Smoking

- Diabetes or other chronic disease

- Antibiotic medication within the past 3 months

- Blood donation within the past month

Locations and Contacts

University of Eastern Finland, Kuopio FI-70211, Finland
Additional Information

Starting date: November 2009
Last updated: April 16, 2012

Page last updated: August 23, 2015

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