A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery
Information source: Turkiye Yuksek Ihtisas Education and Research Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Artery Disease
Intervention: remifentanil (Drug); Ketamine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Turkiye Yuksek Ihtisas Education and Research Hospital Official(s) and/or principal investigator(s):
Aslı Demir, Principal Investigator, Affiliation: Turkey Yuksek Ihtisas Education and Research Hospital
Summary
In this prospective, randomized, clinical trial, we have investigated the effects of
ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-c
levels, and creatinine and/or cystatin-c based eGFR equations in terms of acute kidney
injury in CABG surgery. This study was approved by the Ethics Committee of Hospital and all
patients were informed and gave written consent. Patients scheduled for elective CABG with
cardiopulmonary bypass. Patients were randomly allocated to anesthesia with
remifentanil-propofol-midazolam (RPM) group or ketamine-propofol-midazolam (KPM) group.
Blood samples were obtained before induction of anesthesia (baseline), at the end of the
operation, and postoperative days 1, 2, and 4.
Clinical Details
Official title: A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery
Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Primary outcome: creatinin, BUN
Secondary outcome: Cystatin-c level
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
patients undergoing elective CABG with cardiopulmonary bypass
Exclusion Criteria:
patients undergoing emergency operation, combined operation, off-pump surgery, repeat
surgery or valve surgery, patients presenting with chronic kidney disease or renal
impairment, patients younger than 18 years old and neurological and/or psychiatric
disturbances.
Locations and Contacts
Aslı Demir, Ankara 06100, Turkey
Turkey Yuksek Ihtisas Education and Research Hospital, Ankara 06550, Turkey
Additional Information
TYIH ETHICS COMMITTEE
Starting date: May 2013
Last updated: April 9, 2014
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