Evaluating Electrocardiogram (ECG) Abnormalities From Young Adulthood Through Middle Age
Information source: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cardiovascular Diseases
Phase: N/A
Status: Completed
Sponsored by: National Heart, Lung, and Blood Institute (NHLBI) Official(s) and/or principal investigator(s): Donald M. Lloyd-Jones, MD, ScM, Principal Investigator, Affiliation: Northwestern University Feinberg School of Medicine
Summary
An electrocardiogram (ECG) is a test that evaluates the electrical activity of the heart and
can be used to detect heart problems. By analyzing ECGs collected over a 20-year period,
this study will examine ECG abnormalities and the differences in ECG findings between black
and white people, from young adulthood through middle age.
Clinical Details
Official title: Epidemiology and Mechanisms of ECG Abnormalities: Young Adulthood to Middle Age
Study design: Observational Model: Cohort, Time Perspective: Retrospective
Primary outcome: Development of resting ECG abnormalities, specifically isolated non-specific ST-segment and T-wave abnormalities
Detailed description:
An ECG is a test that detects and records the electrical activity of the heart. As a
diagnostic tool, it can detect and locate the source of heart problems, including heart
attacks, irregular heart beats, cardiovascular disease, or other abnormalities of the heart.
An ECG procedure involves attaching electrodes to the skin on the chest, arms, and legs
while the electrodes detect electrical signals of the heart, and a machine displays the
signals on a computer screen and graph paper. An ECG may be a beneficial way to detect
cardiovascular disease because it is a low-cost and non-invasive test that is widely
available in the clinical setting.
This study will examine ECGs and other study data from participants in the Coronary Artery
Risk Development in Young Adults (CARDIA) study. As ECG abnormalities typically begin to
develop in young adults, the CARDIA participants will provide researchers with an excellent
study population. As part of the CARDIA study, ECGs were obtained from participants at
baseline, and Years 7 and 20. Study researchers will use state-of-the-art technology and
standardized Minnesota Code and Novacode methods to electronically code participants' ECGs
and accomplish the following: 1) assess the frequency of ECG abnormalities in young adults
of different races; 2) examine potential risk factors for the development and progression of
ECG abnormalities; 3) investigate the relationship between ECG abnormalities and other
measures of heart disease; and 4) assess differences in the frequency and patterns of ECG
abnormalities between different racial groups. Study researchers will also analyze
additional CARDIA study data, including cardiovascular disease risk factors, measures of
atherosclerosis, and echocardiographic ultrasound pictures of the heart.
This research will provide important insights into the ways in which ECG abnormalities are
associated with increased risk for cardiovascular disease and how the risk may differ
between blacks and whites. Results from this study may ultimately lead to improvements in
preventive strategies for cardiovascular disease in young adults.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Participated in the CARDIA study
Locations and Contacts
Northwestern University, Chicago, Illinois 60611, United States
Additional Information
Related publications: Cutter GR, Burke GL, Dyer AR, Friedman GD, Hilner JE, Hughes GH, Hulley SB, Jacobs DR Jr, Liu K, Manolio TA, et al. Cardiovascular risk factors in young adults. The CARDIA baseline monograph. Control Clin Trials. 1991 Feb;12(1 Suppl):1S-77S.
Starting date: January 1985
Last updated: December 12, 2007
|