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Low Dose Human Chorionic Gonadotropin: Influence on the Endometrium

Information source: Universitair Ziekenhuis Brussel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Infertility

Intervention: human menopausal gonadotropin (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Universitair Ziekenhuis Brussel

Summary

The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. The study is a randomised trial where 2 groups of patients, undergoing a gonadotropin-releasing hormone antagonist protocol for in vitro fertilization, are studied. In addition to the histological findings, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, the investigators want to study the implantation potential.

Clinical Details

Official title: Influence of Ovarian Stimulation With 200 IU of hCG, (Administered in the Late Follicular Phase Among ICSI Patients Undergoing a GnRH-antagonist Protocol), on the Endometrium on the Day of Oocyte Pick-up

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Primary outcome: number of oocytes

Eligibility

Minimum age: 18 Years. Maximum age: 36 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- < 36 years on day of randomisation

- FSH < 12 in the early follicular phase

- Normal ultrasound scan

- BMI between 18 and 29 (both inclusive)

- Randomisation at outpatient clinic

Exclusion Criteria:

- Endometriosis ≥ grade 3

- PCO syndrome

- Poor responder

- Endocrine or metabolic abnormalities

Locations and Contacts

UZ Brussel, Laarbeeklaan 101, Brussels 1090, Belgium
Additional Information

Starting date: January 2009
Last updated: March 24, 2010

Page last updated: August 23, 2015

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