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Cross-Over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Information source: Case Western Reserve University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Nystagmus, Pathological

Intervention: gabapentin (Drug); memantine (Drug)

Phase: N/A

Status: Completed

Sponsored by: Case Western Reserve University


Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

Clinical Details

Official title: Investigation and Treatment of Ocular Motor Disorders: Cross-Over Comparison of Gabapentin and Memantine as Treatment for Nystagmus

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome:

Visual acuity of each eye, measured during far or near viewing

Median eye speed during attempted visual fixation, of each eye.

Secondary outcome: Patient's report of whether they think that they have benefitted from either drug treatment

Detailed description: The study entails careful measurements of visual acuity and precise measurements of eye movements, using a contact lens device (magnetic search coil method). In this way, it is possible to make objective and reliable measurements of the effect of each drug, which are unbiased by the investigator or the patient.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Adult (18 years or older) males or females with acquired nystagmus that is degrading

their vision Exclusion Criteria:

- Pregnant women

- Individuals who cannot described their visual symptoms, cooperate with testing, or

give informed consent

- Individuals with intolerance of gabapentin or memantine

Locations and Contacts

Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, Ohio 44106, United States
Additional Information

Starting date: February 2005
Last updated: June 25, 2009

Page last updated: August 23, 2015

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