Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen
Information source: Seoul National University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Ibuprofen; Remifentanil; Hyperalgesia; Pain, Postoperative
Intervention: high dose remifentanil (Drug); Ibuprofen (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Seoul National University Hospital
Summary
Postoperative hyperalgesia has been reported after intraoperative administration of small or
high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the
development of opioid-induced hyperalgesia. The aim of this study is to evaluate the
preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Supportive Care
Primary outcome: cumulative morphine consumption
Secondary outcome: Pain score
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Adult patients scheduled for elective pancreaticoduodenectomy
Exclusion Criteria:
- Patients with chronic pain
- Patients with psychiatric disease
- Patients with nonsteroidal antiinflammatory drugs allergy
- Patients with renail dysfunction
- History of drug addiction
- Pregnant patient
- Inability to use a PCA device
Locations and Contacts
Seoul National University Hospital, Seoul, Korea, Republic of; Recruiting
Yunseok Jeon, MD, PhD, Phone: 82-10-9016-2940, Email: jeonyunseok@gmail.com
Yunseok Jeon, MD, PhD, Principal Investigator
Additional Information
Starting date: July 2014
Last updated: September 16, 2014
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