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Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

Information source: Seoul National University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Ibuprofen; Remifentanil; Hyperalgesia; Pain, Postoperative

Intervention: high dose remifentanil (Drug); Ibuprofen (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Seoul National University Hospital


Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Supportive Care

Primary outcome: cumulative morphine consumption

Secondary outcome: Pain score


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Adult patients scheduled for elective pancreaticoduodenectomy

Exclusion Criteria:

- Patients with chronic pain

- Patients with psychiatric disease

- Patients with nonsteroidal antiinflammatory drugs allergy

- Patients with renail dysfunction

- History of drug addiction

- Pregnant patient

- Inability to use a PCA device

Locations and Contacts

Seoul National University Hospital, Seoul, Korea, Republic of; Recruiting
Yunseok Jeon, MD, PhD, Phone: 82-10-9016-2940, Email: jeonyunseok@gmail.com
Yunseok Jeon, MD, PhD, Principal Investigator
Additional Information

Starting date: July 2014
Last updated: September 16, 2014

Page last updated: August 23, 2015

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