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Antiarrythmic Drugs - Long-term Follow-up in the Modern Era

Information source: University of Dundee
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cardiac Dysrhythmia

Phase: N/A

Status: Active, not recruiting

Sponsored by: University of Dundee

Summary

Antiarrhythmic drugs are associated with significant side effect profiles. Amiodarone has primarily class III action and whilst it has unrivalled efficacy in management of certain arrhythmias, it has a formidable side effect profile. Complications of continued therapy include, thyroiditis, hepatitis, cholestasis, increased skin sensitivity and pulmonary fibrosis. Current prescribing guidelines recommend frequent blood tests to monitor kidney, liver and thyroid function, in addition to frequent pulmonary function tests. Sotalol is a betablocker which possesses class III action in high doses and may predispose to QT prolongation Other class I agents such as flecainide and propafenone can be associated with sudden cardiac death in certain populations, and may predispose to other arrhythmias. This study will examine the incidence of discontinuation of AAD therapy and adverse events.

Clinical Details

Official title: Retrospective Record Linkage Study to Investigate the Incidence of Complications and Follow-up Associated With Anti-arrythmic Drug Therapy

Study design: Observational Model: Ecologic or Community, Time Perspective: Retrospective

Primary outcome: Adverse Event

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- At least one prescription for antiarrythmic drug

Locations and Contacts

Univeristy of Dundee, Dundee DD1 9SY, United Kingdom
Additional Information

Starting date: March 2010
Last updated: March 4, 2010

Page last updated: August 23, 2015

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