DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers

Information source: Virginia Commonwealth University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Focus of Study: Absorption of the Three Components in the Topical ABH Gel in Healthy Volunteers, and Determine if There Are Any Adverse Effects.

Intervention: lorazepam (Drug); diphenhydramine hydrochloride (Drug); haloperidol (Drug); questionnaire administration (Other); laboratory biomarker analysis (Other)

Phase: N/A

Status: Completed

Sponsored by: Virginia Commonwealth University

Official(s) and/or principal investigator(s):
Thomas Smith, Principal Investigator, Affiliation: Virginia Commonwealth University


RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into the skin, may be an effective treatment for nausea and vomiting. PURPOSE: This clinical trial studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in healthy volunteers.

Clinical Details

Official title: Absorption of "ABH Gel" (AtivanŽ, Lorazepam; BenadrylŽ, Diphenhydramine; and HaldolŽ, Haloperidol Gel) From the Skin of Normal Volunteers

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Primary outcome: Lorazepam, Diphenyhydramine, Haloperidol Absorption

Secondary outcome: Side Effects

Detailed description: OBJECTIVES: I. To study the absorption of the three components in the topical ABH gel in 10 healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes. After completion of study treatment, patients are followed up for 5 hours.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Completed a medical screening questionnaire

- English speaking

- No allergies to the drugs

- Able to complete the forms

- If a woman of childbearing age, agree to use contraception

Exclusion Criteria:

- History of substance abuse, psychiatric disorder, acquired brain injury, the

possibility of pregnancy (not using birth control, and of child bearing age)

- Use of any medication that would contraindicate benzodiazepine administration

- Pregnant or nursing

Locations and Contacts

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia 23298, United States
Additional Information

Starting date: November 2010
Last updated: April 26, 2013

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017