Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
Information source: Pontificia Universidad Catolica de Chile
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertensive Disease; Pain, Postoperative
Intervention: SBP 20-30% over baseline (Other); SBP 20-30% under baseline (Other)
Phase: Phase 4
Status: Completed
Sponsored by: Pontificia Universidad Catolica de Chile Official(s) and/or principal investigator(s): Alejandro E Delfino, MD, Principal Investigator, Affiliation: Departamento de Anestesiología, Hospital Clínico Pontificia Universidad Católica de Chile
Summary
The purpose of this randomized clinical trial is to evaluate the effect of acute arterial
hypertension maintained during surgery on morphine's requirements in patients undergoing
laparoscopic cholecystectomy
Clinical Details
Official title: Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
Primary outcome: Morphine requirement post laparoscopic cholecystectomy
Secondary outcome: Effects of acute hypertension in pain scores
Detailed description:
The high arterial blood pressure has been correlated with an increase in pain threshold in
animal and humans. One of the explanations to this phenomenon is a baroreceptor activity and
vasopressin release at the level of spinal cord dorsal horn and hypothalamus.
As far as we know, there is only one study about the effect of chronic hypertension on
postoperative pain and none with acute hypertension. We therefore decided to conduct a
randomized controlled trial to evaluate the effect of acute hypertension on postoperative
morphine's requirements.
Eligibility
Minimum age: 20 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- American Society of Anesthesiology patient classification status(ASA) I-II
- Between 20 and 60 years of age
- Programed for elective laparoscopic cholecystectomy
Exclusion Criteria:
- History of arterial hypertension
- Baseline blood pressure over 139/89
- Use of opioids and any analgesic drug during the last 24 hours before surgery
- Chronic use of nonsteroidal antiinflammatory
- BMI > 34. 9
- History of drug or alcohol abuse
- Use of medications that interfere in the central nervous system
- Adverse reactions to the drugs used in the study
- Pregnancy
Locations and Contacts
Hospital Clinico Pontificia Universidad Catolica, Santiago, Region Metropolitana 8330024, Chile
Additional Information
Starting date: January 2010
Last updated: July 8, 2013
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