Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits
Information source: University of Campinas, Brazil
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Irreversible Pulpitis; Pain
Intervention: 4% articaine with 1:100,000 epinephrine (Drug); 2% lidocaine with 1:100,000 epinephrine (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: University of Campinas, Brazil Official(s) and/or principal investigator(s): José FA Almeida, DDS, PhD, Study Chair, Affiliation: Endodontics Area - FOP-UNICAMP Maria RF Monteiro, DDS, MSc, Principal Investigator, Affiliation: Endodontics Area - FOP-UNICAMP
Summary
The aim of this study was to verify the effectiveness of an anesthetic called articaine for
dental treatment, comparing it with an anesthetic commonly used in dental clinic: lidocaine.
Two types of local anesthesia (oral injection) in accordance with the solution used were
performed. For patients anesthetized with articaine, an injection of anesthesia close to the
tooth to be treated was used. For the anesthetic lidocaine an injection on the cheek at the
bottom of the mouth was made. Differences between both techniques are mainly regarding the
area of numbness. In the injection with articaine only a small part of the lip and the tooth
was anesthetized. With lidocaine injection, the lower region of the entire side of the tooth
and half of the tongue on the same side was numbed. The treatment was electronic randomized
and there was equal chance to one or another treatment. The investigators are studying this
new form of anesthesia (near the tooth that was treated) to see if it can numb the tooth to
an emergency treatment, if it really decreases the feeling of numbness and discomfort during
the service. Patients receiving articaine were submitted to cone beam exam at no cost.
Clinical Details
Official title: Anesthetic Efficacy of 4% Articaine (Mandibular Infiltration) and 2% Lidocaine (Alveolar Nerve Block), Associated With 1:100.000 Epinephrine, in Lower Molars With Irreversible Pulpits
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Pain perception 3
Secondary outcome: Buccal cortical bone thicknessRoot distance to the bone Basal pain perception Pain perception 2
Detailed description:
Aim: This randomized clinical trial compared the anesthetic efficacy of buccal infiltration
(BI) with 4% articaine (AR) and inferior alveolar nerve block (IANB) with 2% lidocaine (LI),
both with 1: 100,000 epinephrine, in symptomatic mandibular molars with irreversible
pulpitis. Likewise, we compared the efficacy of the primary infiltration (BI or IANB) with
one supplemental injection (intraligamentary infiltration with articaine for AR and BI with
articaine for LI). The influences of buccal cortical bone thickness and root distances to
buccal cortical bone on articaine performance (AR) were also evaluated using cone-beam
tomography. methodology: Volunteers presenting symptomatic mandibular molars with
irreversible pulpitis were randomly divided into two groups (30 for AR and 20 for LI).
Success was recorded when complete pain-free treatment was achieved after primary injection
or when one supplemental injection was needed for emergency endodontic procedures.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- long-lasting moderate to severe pain during cold test
- absence of periapical radiolucency except for a widened periodontal ligament
(evaluated in periapical radiographs)
- vital coronal pulp on access opening
Exclusion Criteria:
- Previous history of allergy to local anesthetics
- Subjects with systemic diseases
- Pregnancy and lactation
- Subjects taking any kind of medication that could change or influence the outcome of
this research
- Subjects without painful symptoms
- Negative thermal testing, periapical lesion, incomplete root formation, presence of
fistula or abscess, cracks or fractures
Locations and Contacts
Piracicaba Dental School - UNICAMP, Piracicaba, SP 13414-903, Brazil
Additional Information
Related publications: Aggarwal V, Jain A, Kabi D. Anesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine after an inferior alveolar nerve block in patients with irreversible pulpitis. J Endod. 2009 Jul;35(7):925-9. doi: 10.1016/j.joen.2009.04.012. Ashraf H, Kazem M, Dianat O, Noghrehkar F. Efficacy of articaine versus lidocaine in block and infiltration anesthesia administered in teeth with irreversible pulpitis: a prospective, randomized, double-blind study. J Endod. 2013 Jan;39(1):6-10. doi: 10.1016/j.joen.2012.10.012. Epub 2012 Nov 13. Berlin J, Nusstein J, Reader A, Beck M, Weaver J. Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Mar;99(3):361-6.
Starting date: February 2010
Last updated: July 29, 2013
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