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The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy

Information source: Inonu University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Haemodynamic Rebound

Intervention: Sevoflurane (Drug); Remifentanil (Drug); Saline (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Inonu University

Official(s) and/or principal investigator(s):
Feray Erdil, MD, Principal Investigator, Affiliation: Ä°nonu Univercity Medical Faculty Department of Anestheisology and Reanimation

Overall contact:
Feray Erdil, MD, Phone: +90 422 341 06 60, Ext: 3148, Email: feray.erdil@inonu.edu.tr


The investigators will be evaluated the effects of a single loading dose of remifentanil (1µg/kg), administered as an adjunct to sevoflurane, on duration of hemodynamic profile, seizure activity, and recovery times during electroconvulsive therapy (ECT) in patients with major depression

Clinical Details

Official title: Inonu University, Turgut Ozal Medical Center, Department of Anesthesiology and Reanimation Malatya

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: The effects of remifentanil on the heart rate after electroconvulsive therapy

Secondary outcome:

Seizure duration

The effects of remifentanil on the mean arterial pressure after electroconvulsive therapy

Detailed description: Major depressive patients will enrolled this trial. Mean arterial pressure (MAP) and heart rate (HR) and peripheral oxygen saturation values will be recorded prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 minute after the seizure have ended (T3, T4, T5, and T6, respectively). The peak heart rate during the seizure will be recorded from the Electrocardiogram.


Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- Major depressive patients

Exclusion Criteria:

- younger than 18 years, pregnant, had a history of myocardial infarction in the

previous six months, atrial fibrillation or flutter, heart block, unregulated hypertension, cerebrovascular diseases, known drug allergy.

Locations and Contacts

Feray Erdil, MD, Phone: +90 422 341 06 60, Ext: 3148, Email: feray.erdil@inonu.edu.tr

Turgut Ozal Medical Center, Malatya 44315, Turkey
Additional Information

Starting date: October 2014
Last updated: October 20, 2014

Page last updated: August 23, 2015

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