The Effects of Remifentanil on Attenuating the Hemodynamic Responses After Electroconvulsive Therapy
Information source: Inonu University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Haemodynamic Rebound
Intervention: Sevoflurane (Drug); Remifentanil (Drug); Saline (Drug)
Phase: Phase 4
Status: Not yet recruiting
Sponsored by: Inonu University Official(s) and/or principal investigator(s):
Feray Erdil, MD, Principal Investigator, Affiliation: Ä°nonu Univercity Medical Faculty Department of Anestheisology and Reanimation
Overall contact:
Feray Erdil, MD, Phone: +90 422 341 06 60, Ext: 3148, Email: feray.erdil@inonu.edu.tr
Summary
The investigators will be evaluated the effects of a single loading dose of remifentanil
(1µg/kg), administered as an adjunct to sevoflurane, on duration of hemodynamic profile,
seizure activity, and recovery times during electroconvulsive therapy (ECT) in patients with
major depression
Clinical Details
Official title: Inonu University, Turgut Ozal Medical Center, Department of Anesthesiology and Reanimation Malatya
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: The effects of remifentanil on the heart rate after electroconvulsive therapy
Secondary outcome: Seizure durationThe effects of remifentanil on the mean arterial pressure after electroconvulsive therapy
Detailed description:
Major depressive patients will enrolled this trial. Mean arterial pressure (MAP) and heart
rate (HR) and peripheral oxygen saturation values will be recorded prior to anesthetic
induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 minute after the
seizure have ended (T3, T4, T5, and T6, respectively). The peak heart rate during the
seizure will be recorded from the Electrocardiogram.
Eligibility
Minimum age: 18 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Major depressive patients
Exclusion Criteria:
- younger than 18 years, pregnant, had a history of myocardial infarction in the
previous six months, atrial fibrillation or flutter, heart block, unregulated
hypertension, cerebrovascular diseases, known drug allergy.
Locations and Contacts
Feray Erdil, MD, Phone: +90 422 341 06 60, Ext: 3148, Email: feray.erdil@inonu.edu.tr
Turgut Ozal Medical Center, Malatya 44315, Turkey
Additional Information
Starting date: October 2014
Last updated: October 20, 2014
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