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Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)

Information source: Robert Bosch Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Vasospasm; Microvascular Angina; Coronary Artery Disease

Intervention: Intracoronary acetylcholine provocation test (Other)

Phase: N/A

Status: Recruiting

Sponsored by: Peter Ong, MD

Official(s) and/or principal investigator(s):
Peter Ong, MD, Principal Investigator, Affiliation: Robert Bosch Medical Center
Anastasios Athanasiadis, MD, Study Chair, Affiliation: Robert Bosch Medical Center
Udo Sechtem, MD, Study Director, Affiliation: Robert Bosch Medical Center

Overall contact:
Peter Ong, MD, Phone: +447745624863, Email: petereong@gmail.com

Summary

In patients with chest pain and/or shortness of breath coronary artery disease (CAD) is suspected depending on the pattern of symptoms and the electrocardiogram (ECG). Coronary angiography is the method of choice to verify this suspicion. If the patient coronary arteries on coronary angiography are totally normal, one can only speculate if the patients' discomfort is from the heart or not. A possibility to get further information about the healthiness of the coronary arteries is the acetylcholine test (ACH-test). When injecting this natural, body produced-substance into the coronary arteries one can test if the vessels coronary spasm which can be the reason for the patient's symptoms. The investigators therefore use this test in this study to look for coronary spasm in patients with suspected CAD but normal coronary arteries. In case of a positive test, the patient profits from having found a cause for his/her symptoms making treatment with special tablets possible. Furthermore, the investigators want to analyze blood samples of every patient to look for signs of inflammation that seem to be linked with coronary spasms. On the basis of these results the ACH-test could probably be avoided in the future.

Clinical Details

Official title: Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Primary outcome: all cause mortality (cardiac vs. non-cardiac)

Secondary outcome: Angina pectoris, repeated angiography, re-admissions for angina pectoris

Eligibility

Minimum age: 35 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Adults between 35 and 95 years old with angina pectoris and/or dyspnea suggestive of

coronary artery disease with non-invasive proof of coronary ischemia or high pre-test probability for CAD who will be referred for coronary angiography

- Serum creatinine < 1,4 md/dl

- Left ventricular ejection fraction > 50%

Exclusion Criteria:

- Patients under 35 years and above 95 years of age

- Severe chronic obstructive pulmonary disease (contraindication for

acetylcholine-testing)

Locations and Contacts

Peter Ong, MD, Phone: +447745624863, Email: petereong@gmail.com

Robert Bosch Medical Center, Stuttgart 70376, Germany; Recruiting
Peter Ong, MD, Phone: +447745624863, Email: petereong@gmail.com
Anastasios Athanasiadis, MD, Phone: +4971181015444
Additional Information

Starting date: November 2007
Last updated: December 29, 2014

Page last updated: August 23, 2015

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