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Magnetic Resonance Imaging Study of Geriatric Depression

Information source: Mclean Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Major Depressive Disorder

Intervention: Sertraline (Drug)

Phase: N/A

Status: Completed

Sponsored by: Mclean Hospital

Official(s) and/or principal investigator(s):
Brent Forester, M.D, Principal Investigator, Affiliation: Mclean Hospital

Summary

The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.

Clinical Details

Official title: Nuclear Magnetic Resonance Imaging Study of Treatment With Sertraline in Geriatric Depression

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

HAM-D 17 (Hamilton Depression Rating Scale)

Geriatric Depression Scale

MRS (Magnetic Resonance Spectroscopy)

Eligibility

Minimum age: 55 Years. Maximum age: 89 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- DSM- IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition)

diagnostic criteria for major depressive disorder

- Hamilton Depression Scale- 17 item version score of 18 or higher

- Must speak English

- Women must be post-menopausal

Exclusion Criteria:

- A current or pervious psychiatric disorder other than MDD

- A current unstable medical condition

- A pacemaker or metal implant

- History of alcohol or drug dependence or abuse within the past year

- Current prescription of excluded medications

- Use of a drug within the last 30 days that was not approved for use by governmental

authorities.

- If you or a family member works at McLean Hospital

Locations and Contacts

McLean Hospital, Belmont, Massachusetts 02478, United States
Additional Information

Starting date: November 2004
Last updated: April 6, 2015

Page last updated: August 23, 2015

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