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A Phase 1 Parallel-Group, Double-Blind, Placebo-Controlled Cardiovascular and Behavioral Study Assessing Interactions Between Single Doses of Oral Reserpine and Intravenous Methamphetamine - 1

Information source: National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Amphetamine-Related Disorders

Intervention: Reserpine (Drug)

Phase: Phase 1

Status: Active, not recruiting

Sponsored by: National Institute on Drug Abuse (NIDA)

Official(s) and/or principal investigator(s):
Reese Jones, M.D., Principal Investigator, Affiliation: Langley Porter Psychiatric Institute

Summary

In this parallel group clinical pharmacology laboratory experiment, we will assess pharmacodynamic interactions (with a focus on cardiovascular effects) of a 15 mg intravenous methamphetamine dose and single oral doses of reserpine (0. 5 and 1. 0 mg) or placebo.

Clinical Details

Official title: Assessment of Interactions Between IV Methamphetamine and Reserpine

Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Primary outcome:

Craving

Cardiovascular

Subjective symptoms/Mood Effects

CNS norepinephrine turnover

Detailed description: In this parallel group clinical pharmacology laboratory experiment, we will assess pharmacodynamic interactions (with a focus on cardiovascular effects) of a 15 mg intravenous methamphetamine dose and single oral doses of reserpine (0. 5 and 1. 0 mg) or placebo.

Eligibility

Minimum age: 21 Years. Maximum age: 45 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Please contact site for more details

Exclusion Criteria:

- Please contact site for more details

Locations and Contacts

U of CA, San Francisco, San Francisco, California 94143, United States
Additional Information

Starting date: January 2004
Last updated: October 25, 2007

Page last updated: August 23, 2015

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