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Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs

Information source: Universidade Federal do ParanŠ
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Glaucoma, Narrow Angle

Intervention: YAG laser peripheral iridotomy (Procedure); YAG laser peripheral iridotomy (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: Universidade Federal do ParanŠ

Official(s) and/or principal investigator(s):
Lucas Shiokawa, MD, Principal Investigator, Affiliation: Universidade Federal do Parana

Overall contact:
Lucas Shiokawa, MD, Phone: 55 41 91432398, Email: lucasshiokawa@yahoo.com.br

Summary

The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0. 1% vs. 0. 2% after laser peripheral iridotomy (LPI).

Clinical Details

Official title: Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention

Primary outcome: intra-ocular pressure increase

Detailed description: Postoperative IOP elevation is one of the most common complications after LPI. Previous studies showed that brimonidine 0. 2% is effective in blunting IOP spikes after LPI. This prospective randomized double-masked interventional study will include patients with bilateral narrow angles, defined by irido-trabecular contact in >180o on gonioscopy. Pilocarpine 1% will be used in both eyes, and 30 minutes later, brimonidine 0. 1% randomly used in one eye and brimonidine 0. 2% in the contra-lateral eye. LPI with Nd: YAG laser is performed 30 minutes later in both eyes by a single glaucoma specialist. IOP measurements are assessed before the use of any eyedrop (basal IOP), 30 minutes after pilocarpine (pre-brimonidine), and 30, 60, 120, 180 minutes after LPI. Pachymetry, ultrasonic biometry, gonioscopy, and total YAG laser energy are recorded. Non-parametric test will be used for analysis.

Eligibility

Minimum age: 40 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- bilateral narrow angles, defined by irido-trabecular contact in >180o on gonioscopy

Exclusion Criteria:

- previous cataract surgery

Locations and Contacts

Lucas Shiokawa, MD, Phone: 55 41 91432398, Email: lucasshiokawa@yahoo.com.br

Universidade Federal do Parana, Curitiba, Parana 80060-150, Brazil; Recruiting
Lucas Shiokawa, Principal Investigator
Lisandro Sakata, Principal Investigator
Dayane Issaho, Principal Investigator
Additional Information

Related publications:

Brazier DJ. Neodymium-YAG laser iridotomy. J R Soc Med. 1986 Nov;79(11):658-60.

Chen TC, Ang RT, Grosskreutz CL, Pasquale LR, Fan JT. Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Ophthalmology. 2001 Jun;108(6):1033-8.

Chen TC. Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery. J Cataract Refract Surg. 2005 Sep;31(9):1707-12.

Drake MV. Neodymium:YAG laser iridotomy. Surv Ophthalmol. 1987 Nov-Dec;32(3):171-7. Review.

Hartenbaum D, Wilson H, Maloney S, Vacarelli L, Orillac R, Sharpe E. A randomized study of dorzolamide in the prevention of elevated intraocular pressure after anterior segment laser surgery. Dorzolamide Laser Study Group. J Glaucoma. 1999 Aug;8(4):273-5.

Kashiwagi K, Abe K, Tsukahara S. Quantitative evaluation of changes in anterior segment biometry by peripheral laser iridotomy using newly developed scanning peripheral anterior chamber depth analyser. Br J Ophthalmol. 2004 Aug;88(8):1036-41.

Khodadoust AA, Arkfeld DF, Caprioli J, Sears ML. Ocular effect of neodymium-YAG laser. Am J Ophthalmol. 1984 Aug 15;98(2):144-52.

Robin AL, Arkell S, Gilbert SM, Goossens AA, Werner RP, Korshin OM. Q-switched neodymium-YAG laser iridotomy. A field trial with a portable laser system. Arch Ophthalmol. 1986 Apr;104(4):526-30.

Schrems W, Eichelbrönner O, Krieglstein GK. The immediate IOP response of Nd-YAG-laser iridotomy and its prophylactic treatability. Acta Ophthalmol (Copenh). 1984 Oct;62(5):673-80.

Wetzel W. Ocular aqueous humor dynamics after photodisruptive laser surgery procedures. Ophthalmic Surg. 1994 May;25(5):298-302.

Starting date: November 2010
Last updated: August 15, 2011

Page last updated: August 20, 2015

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