Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs

Condition(s) targeted: Glaucoma, Narrow Angle

Intervention: YAG laser peripheral iridotomy (Procedure); YAG laser peripheral iridotomy (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: Universidade Federal do Paraná

Official(s) and/or principal investigator(s):
Lucas Shiokawa, MD, Principal Investigator, Affiliation: Universidade Federal do Parana

Overall contact:
Lucas Shiokawa, MD, Phone: 55 41 91432398, Email: lucasshiokawa@yahoo.com.br

The purpose of this study is to compare the intra-ocular (IOP) control efficacy between brimonidine 0. 1% vs. 0. 2% after laser peripheral iridotomy (LPI).

Official title: Short-term Intraocular Pressure Control After YAG Iridotomy - Comparison Between Brimonidine 0.1% vs. 0.2%

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention

Primary outcome: intra-ocular pressure increase

Detailed description: Postoperative IOP elevation is one of the most common complications after LPI. Previous studies showed that brimonidine 0. 2% is effective in blunting IOP spikes after LPI. This prospective randomized double-masked interventional study will include patients with bilateral narrow angles, defined by irido-trabecular contact in >180o on gonioscopy. Pilocarpine 1% will be used in both eyes, and 30 minutes later, brimonidine 0. 1% randomly used in one eye and brimonidine 0. 2% in the contra-lateral eye. LPI with Nd: YAG laser is performed 30 minutes later in both eyes by a single glaucoma specialist. IOP measurements are assessed before the use of any eyedrop (basal IOP), 30 minutes after pilocarpine (pre-brimonidine), and 30, 60, 120, 180 minutes after LPI. Pachymetry, ultrasonic biometry, gonioscopy, and total YAG laser energy are recorded. Non-parametric test will be used for analysis.

Minimum age: 40 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- bilateral narrow angles, defined by irido-trabecular contact in >180o on gonioscopy

Exclusion Criteria:

- previous cataract surgery

Lucas Shiokawa, MD, Phone: 55 41 91432398, Email: lucasshiokawa@yahoo.com.br

Universidade Federal do Parana, Curitiba, Parana 80060-150, Brazil; Recruiting
Lucas Shiokawa, Principal Investigator
Lisandro Sakata, Principal Investigator
Dayane Issaho, Principal Investigator

Related publications:

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Chen TC. Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery. J Cataract Refract Surg. 2005 Sep;31(9):1707-12.

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Starting date: November 2010
Last updated: August 15, 2011