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Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation

Information source: Inje University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Psychomotor Agitation

Intervention: Midazolam (Drug); Ketamine (Drug)

Phase: N/A

Status: Completed

Sponsored by: Inje University

Official(s) and/or principal investigator(s):
Kihwa Lee, MD, Study Chair, Affiliation: Haeundae paik hospital, inje university


Compare the effects of intravenous midazolam and ketamine on emergence agitation after sevoflurane anesthesia

Clinical Details

Official title: Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation : a Randomized Controlled Trial

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Emergence Agitation

Detailed description: Emergence agitation is self-limiting aggressive behavior that develops in the early period of awakening from anesthesia. A high level of preoperative anxiety is a risk factor for emergence agitation using Aono's four-point scale. Midazolam and ketamine was administered to the patients to decrease of preoperative anxiety. We aimed to compare the emergence agitation between midazolam group and ketamine group.


Minimum age: 2 Years. Maximum age: 6 Years. Gender(s): Both.


Inclusion Criteria:

- American society of anesthesiologists physical status 1-2 aged 2-6 years old, who

were scheduled to undergo ophthalmic surgery (<2hr) Exclusion Criteria:

- children with central nervous system disorders,history of allergy to the study drugs

(midazolam and ketamine), history of recent respiratory tract infection

Locations and Contacts

Additional Information

Starting date: January 2013
Last updated: October 9, 2014

Page last updated: August 23, 2015

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