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A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus

Information source: St. John's Health System, Missouri
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cesarean Section

Intervention: Meperidine (Drug)

Phase: N/A

Status: Not yet recruiting

Sponsored by: St. John's Health System, Missouri

Official(s) and/or principal investigator(s):
Christy L Morgan, MD, Principal Investigator, Affiliation: Mercy Hospital St. Louis

Overall contact:
Christy L Morgan, MD, Phone: 3148140802, Email: christylmorgan@yahoo.com

Summary

The purpose of this study is to determine if epidural meperidine administered by patient-controlled bolus button is equivalent to a low dose infusion plus patient-controlled bolus.

Clinical Details

Official title: A Comparison of Meperidine for Post-Cesarean Analgesia: Bolus Versus Infusion and Bolus

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Verbal Pain Score with movement

Secondary outcome:

Nausea and vomiting

Pruritus

Dysphoria

Inadequate analgesia

Patient Satisfaction

Adverse outcomes

Total drug dose

Detailed description: The objective of this study is to compare the efficacy, patient satisfaction, and incidence of side effects of meperidine patient-controlled epidural analgesia (PCEA) with and without a basal infusion for post-cesarean section analgesia.

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Female.

Criteria:

Inclusion Criteria are as follows:

- Over the age of 18

- Undergoing non-urgent, non-emergent cesarean section at Mercy Hospital St. Louis

Exclusion Criteria:

- non-English speaking

- mentally disabled

- allergy to meperidine

- seizure disorder

- renal impairment defined as a serum creatinine >0. 8 mg/dL or patients who give a

history of renal impairment

- fever greater than 101

- patients receiving low molecular weight heparin at any dose or unfractionated heparin

at doses greater than 5000 u subcutaneous BID

- pre-eclampsia requiring magnesium due to post-partum room assignment

- obstructive sleep apnea due to post-partum room assignment

- post-partum hemorrhage due to post-partum room assignment

Locations and Contacts

Christy L Morgan, MD, Phone: 3148140802, Email: christylmorgan@yahoo.com

Mercy Hospital St. Louis, St. Louis, Missouri 63141, United States
Additional Information

Starting date: March 2013
Last updated: January 1, 2013

Page last updated: August 23, 2015

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