This was a 10-week, placebo-controlled, randomized study to investigate the effect of
injectable IL-1B antagonist, Canakinumab , in participants with impaired glucose tolerance
or Type 2 Diabetes Mellitus (T2DM) already treated on different background diabetes
therapies.
Mean Change in Meal Stimulated Insulin Secretion Rate (ISR) Relative to Glucose 2-4 Hours, From Baseline to 4 WeeksMean Change in Meal Stimulated Insulin Secretion Rate (ISR) Relative to Glucose 0-4 Hours, From Baseline to 4 Weeks.
Mean Change in Fasting Plasma Glucose, From Baseline to 4 Weeks
Mean Change in Fructosamine, From Baseline to 4 Weeks
Mean Change in Fasting Plasma Insulin, From Baseline to 4 Weeks
Mean Change in Quantitative Insulin Sensitivity Check Index (QUICKI) Score, From Baseline to 4 Weeks
Mean Change in Fasting Glucose Disposition Index(GDI)1 and Index 2, From Baseline to 4 Weeks
Mean Change in Absolute Glucose Level at 2 Hours, From Baseline to 4 Weeks
Mean Change in Insulin Area Under the Curve (AUC) 0-4 Hours, From Baseline to 4 Weeks
Mean Change in C-peptide Area Under the Curve (AUC), 0-4 Hours, From Baseline to 4 Weeks
Mean Change in Post-prandial Glucose Area Under the Curve (AUC)0-4 Hours, From Baseline to 4 Weeks
Mean Change in Peak Plasma Glucose, From Baseline to 4 Weeks
Mean Change in Peak Plasma Insulin, From Baseline to 4 Weeks
Mean Change in Peak Plasma C-peptide Level, From Baseline to 4 Weeks
Number of Participants Reporting Death, Serious Adverse Events (SAEs) and Adverse Events (AEs) Above 5% Frequency, From Baseline to 4 Weeks
Minimum age: 18 Years.
Maximum age: 74 Years.
Gender(s): Both.
Lihavuustutkimusyksikkö, Helsinki, Finland
Lääkärikeskus Mehiläinen Töölö, Helsinki, Finland
ODL Terveys Oy, Oulu, Finland
Clintrial Berlin Praxis fuer medizinische Studien, Berlin, Germany
Klinische Forschung Berlin-Buch Dr. Andrei Khariouzov, Berlin, Germany
"Sana Krankenhaus Gerresheim, Duesseldorf, Germany
Gemeinschaftspraxis Dr. Ingo Zeissig, Duisburg, Germany
Praxis Dr. Thorsten Rau, Essen, Germany
Praxis Dr. med. Joerg Luedemann, Falkensee, Germany
Dr. Helmut Anderten Gemeinschaftspraxis Dres. Anderten und Krok, Hildesheim, Germany
Praxis Dr. Julia Chevts, Karlsruhe, Germany
Pro Scientia Med, Luebeck, Germany
Praxis Dr. Winfried Keuthage, Muenster, Germany
Praxis Dr. Uwe Boeckmann, Neumuenster, Germany
Dr. Klaus Funke IkFE Studiencenter Potsdam GMBH I.G., Potsdam, Germany
Praxis Dr. Gerhard Steinmaier, Viernheim, Germany
Praxis Dr. Reinhold U. Schneider, Wetzlar-Naunheim, Germany
Policlinico A.Gemelli - Univ.Cattolica del Sacro Cuore, Roma, Italy
Visakha Diabetes & Endocrine Centre, Visakhapatnam, AP, India
Azienda Ospedaliera-Ospedali Riuniti di BergamoU, Bergamo, BG, Italy
National Research Institute, Los Angeles, California, United States
Crest Clinical Trials, Santa Ana, California, United States
Encompass Clinical Research, Spring Valley, California, United States
Az. Ospedaliera Universit. S.Martino-Universita degli Studi, Genova, GE, Italy
Bangalore Diabetes Hospital,, Banglore, KAR, India
Jnana Sanjeevini Medical Center, Bangalore, Kar, India
Commonwealth Biomedical Research LLC, Madisonville, Kentucky, United States
Health & Research Centre, Trivandrum, Ker, India
Azienda Ospedaliera S. Paolo-Polo Universitario, Milano, MI, Italy
Diabetes Thyroid Hormone Research Institute Pvt .Ltd., Indore, MP, India
Sahyadri Hospital Bibewewadi Centre of Excellence for Diabetics, Pune, Mah, India
Indrayani Speciality Hospital,, Nagpur, Maharastra, India
Fondazione Centro San Raffaele del Monte Tabor-IRCCSUnità, Milano, Mi, Italy
University of Nebraska Medical Center, Omaha, Nebraska, United States
VA Medical Center, Omaha, Nebraska, United States
Lillestol Research LLC, Fargo, North Dakota, United States
Lifestyle Metabolism Centre (Etobicoke), Etobicoke, Ontario, Canada
LMC Endocrinology Centres (Markham) Ltd, Markham, Ontario, Canada
LMC Endocrinology Centres (Thornhill) Ltd, Thornhill, Ontario, Canada
Az. Ospedaliera Della Prov.di Pavia, Casorate Primo, PV, Italy
Preferred Primary Care Physicians, Pittsburgh, Pennsylvania, United States
Centre de recherche clinique de Laval, Laval, Quebec, Canada
Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada
A.O.Universitaria Senese, Universita degli Studi di Siena, Siena, SI, Italy
Madras Diabetes Research Foundation, Chennai, TN, India
Dallas Diabetes and Endocrine Center, Dallas, Texas, United States
Texas Center for Drug Development P.A., Houston, Texas, United States
S.C.D.U. Endocrinologia e Malattie del Metabolismo, Torino, To, Italy
Utah Clinical Trials, Salt Lake City, Utah, United States
Barwon Health - Geelong Hospital, Geelong, Victoria, Australia
Austin Health - Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria, Australia
Melbourne Health - Royal Melbourne Hospital, Melbourne, Victoria, Australia